XZ-259, a strand transfer inhibitor of HIV-1 (HIV-1 integrase inhibitor), was vital in exploring the role of drug resistance mutations (G118R, Q148K) on the viral enzyme integrase (IN) inhibitor selectivity. Unlike raltegravir and elvitegravir, current agents for HIV treatment, XZ-259 was able to successfully inhibit the activity of integrases with the Q148K mutation, demonstrating the potential of XZ-259 as a treatment for HIV-1.
MedKoo Cat#: 130179
Name: XZ-259
CAS#: N/A
Chemical Formula: C17H16ClFN2O5S
Exact Mass: 414.0452
Molecular Weight: 414.83
Elemental Analysis: C, 49.22; H, 3.89; Cl, 8.55; F, 4.58; N, 6.75; O, 19.28; S, 7.73
The following data is based on the product molecular weight 414.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
