QYL-685 | CAS#210355-14-9 | methylenecyclopropane nucleoside analogue

MedKoo Cat#: 596780 | Name: QYL-685

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QYL-685 is a methylenecyclopropane nucleoside analogue with a phenylphosphoralaninate moiety.

Chemical Structure

QYL-685

CAS#210355-14-9

Theoretical Analysis

MedKoo Cat#: 596780

Name: QYL-685

CAS#: 210355-14-9

Chemical Formula: C20H24N7O5P

Exact Mass: 473.1577

Molecular Weight: 473.42

Elemental Analysis: C, 50.74; H, 5.11; N, 20.71; O, 16.90; P, 6.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

QYL-685; QYL 685; QYL685;

IUPAC/Chemical Name

methyl ((((Z)-2-((2,6-diamino-9H-purin-9-yl)methylene)cyclopropyl)methoxy)(phenoxy)phosphoryl)-L-alaninate

InChi Key

XHUFBJWIETZGNX-QUADACEYSA-N

InChi Code

InChI=1S/C20H24N7O5P/c1-12(19(28)30-2)26-33(29,32-15-6-4-3-5-7-15)31-10-14-8-13(14)9-27-11-23-16-17(21)24-20(22)25-18(16)27/h3-7,9,11-12,14H,8,10H2,1-2H3,(H,26,29)(H4,21,22,24,25)/b13-9-/t12-,14?,33?/m0/s1

SMILES Code

C[C@@H](C(OC)=O)NP(OC1=CC=CC=C1)(OCC2/C(C2)=C\N3C=NC4=C(N)N=C(N)N=C34)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 473.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yoshimura K, Feldman R, Kodama E, Kavlick MF, Qiu YL, Zemlicka J, Mitsuya H. In vitro induction of human immunodeficiency virus type 1 variants resistant to phosphoralaninate prodrugs of Z-methylenecyclopropane nucleoside analogues. Antimicrob Agents Chemother. 1999 Oct;43(10):2479-83. PubMed PMID: 10508028; PubMed Central PMCID: PMC89504. 2: Uchida H, Kodama EN, Yoshimura K, Maeda Y, Kosalaraksa P, Maroun V, Qiu YL, Zemlicka J, Mitsuya H. In vitro anti-human immunodeficiency virus activities of Z- and E-methylenecyclopropane nucleoside analogues and their phosphoro-L-alaninate diesters. Antimicrob Agents Chemother. 1999 Jun;43(6):1487-90. PubMed PMID: 10348777; PubMed Central PMCID: PMC89303.