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MedKoo Cat#: 130158 | Name: SHP2-targeting PROTAC SP4

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SHP2-targeting PROTAC SP4 is a PROTAC which was developed by connecting pomalidomide with SHP099, and has potential as treatment for SHP2-related diseases, such as various types of cancer. SP4 was found to significantly reduce the growth of Hela cells and promote SHP2 degradation and cell apoptosis.

Chemical Structure

SHP2-targeting PROTAC SP4
SHP2-targeting PROTAC SP4
CAS#2624181-69-5

Theoretical Analysis

MedKoo Cat#: 130158

Name: SHP2-targeting PROTAC SP4

CAS#: 2624181-69-5

Chemical Formula: C42H51Cl2N11O8

Exact Mass: 907.3299

Molecular Weight: 908.84

Elemental Analysis: C, 55.51; H, 5.66; Cl, 7.80; N, 16.95; O, 14.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SHP2-targeting PROTAC SP4; SP4
IUPAC/Chemical Name
4-((14-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)amino)methyl)-1H-1,2,3-triazol-1-yl)-3,6,9,12-tetraoxatetradecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key
PVZCLGQITBYVPH-UHFFFAOYSA-N
InChi Code
InChI=1S/C42H51Cl2N11O8/c1-42(10-13-53(14-11-42)33-25-47-37(38(45)49-33)29-5-2-6-30(43)36(29)44)48-24-27-26-54(52-51-27)15-17-61-19-21-63-23-22-62-20-18-60-16-12-46-31-7-3-4-28-35(31)41(59)55(40(28)58)32-8-9-34(56)50-39(32)57/h2-7,25-26,32,46,48H,8-24H2,1H3,(H2,45,49)(H,50,56,57)
SMILES Code
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN4N=NC(CNC5(C)CCN(C6=NC(N)=C(C7=CC=CC(Cl)=C7Cl)N=C6)CC5)=C4)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 908.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zheng M, Liu Y, Wu C, Yang K, Wang Q, Zhou Y, Chen L, Li H. Novel PROTACs for degradation of SHP2 protein. Bioorg Chem. 2021 May;110:104788. doi: 10.1016/j.bioorg.2021.104788. Epub 2021 Mar 1. PMID: 33706076.