MedKoo Cat#: 558345 | Name: Sodium salicylate
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized by hydrolysis of methyl salicylate (extracted from wintergreen plants or the bark of sweet birch tree) with an excess of sodium hydroxide and heating it under reflux.

Chemical Structure

Sodium salicylate
Sodium salicylate
CAS#54-21-7

Theoretical Analysis

MedKoo Cat#: 558345

Name: Sodium salicylate

CAS#: 54-21-7

Chemical Formula: C7H5NaO3

Exact Mass:

Molecular Weight: 160.10

Elemental Analysis: C, 52.51; H, 3.15; Na, 14.36; O, 29.98

Price and Availability

Size Price Availability Quantity
100g USD 350.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Sodium salicylate; Kerasalicyl; Kerosal; Magsalyl;
IUPAC/Chemical Name
Benzoic acid, 2-hydroxy-, monosodium salt
InChi Key
ABBQHOQBGMUPJH-UHFFFAOYSA-M
InChi Code
InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
SMILES Code
O=C([O-])C1=CC=CC=C1O.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 160.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cramer K, Schmidt V, Richter A, Fuhrmann H, Abraham G, Krautwald-Junghanns ME. [Investigations on the acute, carrageenan-induced inflammatory reaction and pharmacology of orally administered sodium salicylate in turkeys]. Berl Munch Tierarztl Wochenschr. 2015 May-Jun;128(5-6):240-51. German. PubMed PMID: 26054231. 2: Poźniak B, Grabowski T, Motykiewicz-Pers K, Bobrek K, Rak L, Bobusia K, Gaweł A, Świtała M. Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs. PLoS One. 2015 Apr 20;10(4):e0123526. doi: 10.1371/journal.pone.0123526. eCollection 2015. PubMed PMID: 25893240; PubMed Central PMCID: PMC4403852. 3: Madathil SK, Karuppagounder SS, Mohanakumar KP. Sodium salicylate protects against rotenone-induced parkinsonism in rats. Synapse. 2013 Aug;67(8):502-14. doi: 10.1002/syn.21658. Epub 2013 Mar 27. PubMed PMID: 23447126. 4: Wickerath M, Singh NP. Additive cytotoxic effects of dihydroartemisinin and sodium salicylate on cancer cells. Anticancer Res. 2014 Jul;34(7):3399-401. PubMed PMID: 24982346. 5: Gales L, Amorim R, Afonso CM, Carvalho F, Dinis-Oliveira RJ. Decreasing the toxicity of paraquat through the complexation with sodium salicylate: Stoichiometric analysis. Toxicology. 2015 Oct 2;336:96-8. doi: 10.1016/j.tox.2015.08.005. Epub 2015 Aug 20. PubMed PMID: 26298007. 6: Liu F, Pauluhn J, Trübel H, Wang C. Single high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in rats. Toxicology. 2014 Jan 6;315:17-23. doi: 10.1016/j.tox.2013.11.005. Epub 2013 Nov 23. PubMed PMID: 24280380. 7: Gholami M, Moradpour F, Semnanian S, Naghdi N, Fathollahi Y. Chronic sodium salicylate administration enhances population spike long-term potentiation following a combination of theta frequency primed-burst stimulation and the transient application of pentylenetetrazol in rat CA1 hippocampal neurons. Eur J Pharmacol. 2015 Nov 15;767:165-74. doi: 10.1016/j.ejphar.2015.10.021. Epub 2015 Oct 22. PubMed PMID: 26481164. 8: Poźniak B, Świtała M, Jaworski K, Okoniewski P, Niewiński P. Comparative pharmacokinetics of acetylsalicylic acid and sodium salicylate in chickens and turkeys. Br Poult Sci. 2013;54(4):538-44. doi: 10.1080/00071668.2013.809403. PubMed PMID: 23906222. 9: Klimek VM, Dolezal EK, Smith L, Soff G, Nimer SD. Phase I trial of sodium salicylate in patients with myelodysplastic syndromes and acute myelogenous leukemia. Leuk Res. 2012 May;36(5):570-4. doi: 10.1016/j.leukres.2011.10.023. Epub 2011 Dec 9. PubMed PMID: 22154022. 10: Bergamasco L, Coetzee JF, Gehring R, Murray L, Song T, Mosher RA. Effect of intravenous sodium salicylate administration prior to castration on plasma cortisol and electroencephalography parameters in calves. J Vet Pharmacol Ther. 2011 Dec;34(6):565-76. doi: 10.1111/j.1365-2885.2011.01269.x. Epub 2011 Feb 9. PubMed PMID: 21303378. 11: He B, Zhao S, Zhang W, Li Y, Han P. Effect of sodium salicylate on oxidative stress and insulin resistance induced by free fatty acids. Hepatobiliary Pancreat Dis Int. 2010 Feb;9(1):49-53. PubMed PMID: 20133229. 12: Poźniak B, Switała M, Bobrek K, Graczyk S, Dzimira S. Adverse effects associated with high-dose acetylsalicylic acid and sodium salicylate treatment in broilers. Br Poult Sci. 2012;53(6):777-83. doi: 10.1080/00071668.2012.745929. PubMed PMID: 23398422. 13: Bau JT, Kurz EU. Structural determinants of the catalytic inhibition of human topoisomerase IIα by salicylate analogs and salicylate-based drugs. Biochem Pharmacol. 2014 Jun 15;89(4):464-76. doi: 10.1016/j.bcp.2014.03.011. Epub 2014 Mar 30. PubMed PMID: 24695359. 14: Liu Y, Li X. Effects of salicylate on voltage-gated sodium channels in rat inferior colliculus neurons. Hear Res. 2004 Jul;193(1-2):68-74. PubMed PMID: 15219321. 15: Chen GD, Manohar S, Salvi R. Amygdala hyperactivity and tonotopic shift after salicylate exposure. Brain Res. 2012 Nov 16;1485:63-76. doi: 10.1016/j.brainres.2012.03.016. Epub 2012 Mar 13. PubMed PMID: 22464181; PubMed Central PMCID: PMC5319430. 16: Morkoç AC, Hurley WL, Whitmore HL, Gustafsson BK. Bovine acute mastitis: effects of intravenous sodium salicylate on endotoxin-induced intramammary inflammation. J Dairy Sci. 1993 Sep;76(9):2579-88. PubMed PMID: 8227658. 17: Hu SS, Mei L, Chen JY, Huang ZW, Wu H. Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat. Eur J Histochem. 2014 Mar 12;58(1):2294. doi: 10.4081/ejh.2014.2294. PubMed PMID: 24704997; PubMed Central PMCID: PMC3980210. 18: Hurni MA, Noach AB, Blom-Roosemalen MC, de Boer AG, Nagelkerke JF, Breimer DD. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. J Pharmacol Exp Ther. 1993 Nov;267(2):942-50. PubMed PMID: 7504101. 19: Baldridge SL, Coetzee JF, Dritz SS, Reinbold JB, Gehring R, Havel J, Kukanich B. Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning. Am J Vet Res. 2011 Oct;72(10):1305-17. doi: 10.2460/ajvr.72.10.1305. PubMed PMID: 21962272. 20: Rutishauser SC, Stone SL. The effect of sodium salicylate on bile secretion in the dog. J Physiol. 1975 Mar;245(3):549-65. PubMed PMID: 1142217; PubMed Central PMCID: PMC1330805.