BI-811283 | CAS#958226-81-8 | Aurora inhibitor

MedKoo Cat#: 204670 | Name: BI-811283

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BI 811283 is a small molecule inhibitor of the serine/threonine protein kinase Aurora kinase with potential antineoplastic activity. BI 811283 binds to and inhibits Aurora kinases, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.

Chemical Structure

BI-811283

CAS#958226-81-8 (1R3S)

Theoretical Analysis

MedKoo Cat#: 204670

Name: BI-811283

CAS#: 958226-81-8 (1R3S)

Chemical Formula: C28H38F3N7O2

Exact Mass: 561.3039

Molecular Weight: 561.65

Elemental Analysis: C, 59.88; H, 6.82; F, 10.15; N, 17.46; O, 5.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

958226-81-8 (1R3S) 958226-82-9 (1S3R) 1802182-21-3

Synonym

BI811283; BI-811283; BI 811283.

IUPAC/Chemical Name

4-((4-(((1R,3S)-3-(isopropylcarbamoyl)cyclopentyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-methyl-N-(1-methylpiperidin-4-yl)benzamide

InChi Key

CIVZSIICMSDVMF-PZJWPPBQSA-N

InChi Code

InChI=1S/C28H38F3N7O2/c1-17(2)33-25(39)19-7-10-21(15-19)34-24-23(28(29,30)31)16-32-27(36-24)35-20-8-5-18(6-9-20)26(40)38(4)22-11-13-37(3)14-12-22/h5-6,8-9,16-17,19,21-22H,7,10-15H2,1-4H3,(H,33,39)(H2,32,34,35,36)/t19-,21+/m0/s1

SMILES Code

O=C(N(C1CCN(C)CC1)C)C(C=C2)=CC=C2NC3=NC=C(C(F)(F)F)C(N[C@@H]4CC[C@H](C(NC(C)C)=O)C4)=N3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

BI 811283 is being developed by Boehringer Ingelheim for use as an anti-cancer agent. BI 811283 is currently in the early stages of clinical development and is undergoing first in human trials in patients with solid tumors and Acute Myeloid Leukaemia. BI 811283 is a small molecule drug that selectively binds to the ATP binding pocket of the Aurora B Kinase protein, inhibiting its function in cell division. The Aurora B kinase protein (also known as STK12) is one of a family of proteins that plays an essential role in the alignment, movement and separation of chromosomes during cell division. Aurora B kinase is produced in all dividing cells in normal tissue however; the levels of Aurora B kinase are abnormally raised in many types of cancer. Abnormally elevated levels of Aurora B kinase, cause unequal chromosomal separation during cell division, resulting in the formation of cells with abnormal numbers of chromosomes, which are both a cause and driver of cancer. Inhibition of Aurora B kinase by BI 811283 in cancer cells leads to the formation of cells with severely abnormal numbers of chromosomes (polyploid). Counterintuitively, inhibition of Aurora B kinase by BI 811283 actually causes the polyploid cells formed to continue dividing however, because these cells have severe chromosomal abnormalities, they eventually stop dividing or undergo cell death. (source: http://en.wikipedia.org/wiki/BI811283).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 561.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.