TAS2940 is an irreversible pan-ERBB inhibitor with increased brain penetrability for treatment of lung cancers where metastasis has occurred in the brain, as well as glioblastomas, with HER2/EGFR exon 20 insertions and EGFR aberrations. TAS2940 was shown to be effective and increased survival rate of mice in intracranial xenograft models of HER2/EGFR cancers. TAS2940 is currently undergoing phase 1 clinical trials for solid tumors to determine maximum tolerable dosage.
MedKoo Cat#: 130142
Name: TAS2940 free base
CAS#: 2451398-65-3 (free base)
Chemical Formula: C28H30N6O2
Exact Mass: 482.2430
Molecular Weight: 482.59
Elemental Analysis: C, 69.69; H, 6.27; N, 17.41; O, 6.63
The following data is based on the product molecular weight 482.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
