NSC-194308 | CAS#90379-42-3 | U2AF–RNA Enhancer

MedKoo Cat#: 556801 | Name: NSC-194308

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-194308 is an U2AF–RNA Enhancer. that increased, rather than reduced, association of the U2AF1–U2AF2–SF1–splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibited pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint.

Chemical Structure

NSC-194308

CAS#90379-42-3 (racemate)

Theoretical Analysis

MedKoo Cat#: 556801

Name: NSC-194308

CAS#: 90379-42-3 (racemate)

Chemical Formula: C12H22N2O3S2

Exact Mass: 306.1072

Molecular Weight: 306.44

Elemental Analysis: C, 47.03; H, 7.24; N, 9.14; O, 15.66; S, 20.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

40283-69-0 (free base) 90379-42-3 (racemate)

Synonym

NSC-194308; NSC194308; NSC 194308;

IUPAC/Chemical Name

S-(2-((((1S,2R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl)methyl)amino)-2-iminoethyl) O-hydrogen sulfurothioate

InChi Key

VOOABHIKMGRJFC-GUBZILKMSA-N

InChi Code

InChI=1S/C12H22N2O3S2/c1-12(2)9-4-3-8(10(12)5-9)6-14-11(13)7-18-19(15,16)17/h8-10H,3-7H2,1-2H3,(H2,13,14)(H,15,16,17)/t8-,9-,10-/m0/s1

SMILES Code

C(NC(CSS(=O)(=O)O)=N)[C@H]1[C@]2(C(C)(C)[C@](C2)(CC1)[H])[H]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 306.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL. A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex. Cell Chem Biol. 2021 Aug 19;28(8):1145-1157.e6. doi: 10.1016/j.chembiol.2021.02.007. Epub 2021 Mar 8. PMID: 33689684; PMCID: PMC8380659.