MedKoo Cat#: 130117 | Name: NCGC00506440

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCGC00506440 is a WIP1 phosphatase activator with potential to promote anti-oncogenic activity.

Chemical Structure

NCGC00506440
NCGC00506440
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130117

Name: NCGC00506440

CAS#: N/A

Chemical Formula: C25H22F3N5O2

Exact Mass: 481.1726

Molecular Weight: 481.48

Elemental Analysis: C, 62.37; H, 4.61; F, 11.84; N, 14.55; O, 6.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NCGC00506440
IUPAC/Chemical Name
(3-Methoxyphenyl)-[4-[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]piperazin-1-yl]methanone
InChi Key
IMSQAJATIJSSGN-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H22F3N5O2/c1-35-20-7-3-5-18(15-20)24(34)32-12-10-31(11-13-32)23-9-8-22-29-16-21(33(22)30-23)17-4-2-6-19(14-17)25(26,27)28/h2-9,14-16H,10-13H2,1H3
SMILES Code
O=C(C1=CC=CC(OC)=C1)N2CCN(C3=NN4C(C=C3)=NC=C4C5=CC=CC(C(F)(F)F)=C5)CC2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 481.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Clausse V, Fang Y, Tao D, Tagad HD, Sun H, Wang Y, Karavadhi S, Lane K, Shi ZD, Vasalatiy O, LeClair CA, Eells R, Shen M, Patnaik S, Appella E, Coussens NP, Hall MD, Appella DH. Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen. ACS Pharmacol Transl Sci. 2022 Sep 28;5(10):993-1006. doi: 10.1021/acsptsci.2c00147. PMID: 36268125; PMCID: PMC9578142.