MedKoo Cat#: 130107 | Name: VU0606170

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0606170 is a slack channels inhibitor and was shown to successfully decrease the malfunctioning spontaneous firing rate of cortical neurons, providing a potential avenue for achieving an anti-epileptic effect not previously attainable.

Chemical Structure

VU0606170
VU0606170
CAS#879054-55-4

Theoretical Analysis

MedKoo Cat#: 130107

Name: VU0606170

CAS#: 879054-55-4

Chemical Formula: C19H29ClN4O4S

Exact Mass: 444.1598

Molecular Weight: 444.98

Elemental Analysis: C, 51.29; H, 6.57; Cl, 7.97; N, 12.59; O, 14.38; S, 7.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VU0606170
IUPAC/Chemical Name
N-(5-Chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide
InChi Key
MESKWLXKTLBNGU-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H29ClN4O4S/c1-15-5-7-23(8-6-15)29(26,27)24-11-9-22(10-12-24)14-19(25)21-17-13-16(20)3-4-18(17)28-2/h3-4,13,15H,5-12,14H2,1-2H3,(H,21,25)
SMILES Code
O=C(NC1=CC(Cl)=CC=C1OC)CN2CCN(S(=O)(N3CCC(C)CC3)=O)CC2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Spitznagel BD, Mishra NM, Qunies AM, Prael FJ 3rd, Du Y, Kozek KA, Lazarenko RM, Denton JS, Emmitte KA, Weaver CD. VU0606170, a Selective Slack Channels Inhibitor, Decreases Calcium Oscillations in Cultured Cortical Neurons. ACS Chem Neurosci. 2020 Nov 4;11(21):3658-3671. doi: 10.1021/acschemneuro.0c00583. Epub 2020 Oct 14. PMID: 33143429. 2. Qunies AM, Mishra NM, Spitznagel BD, Du Y, Acuña VS, David Weaver C, Emmitte KA. Structure-activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels. Bioorg Med Chem Lett. 2022 Nov 15;76:129013. doi: 10.1016/j.bmcl.2022.129013. Epub 2022 Sep 29. PMID: 36184030.