MedKoo Cat#: 130102 | Name: LJ-4378

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LJ-4378 is an adenosine A2A/A3 receptor-ligand that has both A2AAR agonist and A3AR antagonist activity. LJ-4378 has potential to treat/prevent obesity-related metabolic diseases and moreover, was found to increase expression levels of both brown adipocyte markers, and mitochondrial proteins.

Chemical Structure

LJ-4378
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130102

Name: LJ-4378

CAS#: N/A

Chemical Formula: C15H19N5O2S

Exact Mass: 333.1259

Molecular Weight: 333.41

Elemental Analysis: C, 54.04; H, 5.74; N, 21.01; O, 9.60; S, 9.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LJ-4378; LJ 4378; LJ4378
IUPAC/Chemical Name
2R,3R,4S)-2-(6-Amino-2-(hex-1-yn-1-yl)-9H-purin-9-yl)tetrahydrothiophene-3,4-diol
InChi Key
VQABXXYIDMPKKB-DDHOLCJHSA-N
InChi Code
InChI=1S/C15H19N5O2S/c1-2-3-4-5-6-10-18-13(16)11-14(19-10)20(8-17-11)15-12(22)9(21)7-23-15/h8-9,12,15,21-22H,2-4,7H2,1H3,(H2,16,18,19)/t9-,12-,15-/m1/s1
SMILES Code
O[C@H]1[C@H](N2C=NC3=C(N)N=C(C#CCCCC)N=C23)SC[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 333.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Kim K, Im H, Son Y, Kim M, Tripathi SK, Jeong LS, Lee YH. Anti-obesity effects of the dual-active adenosine A2A/A3 receptor-ligand LJ-4378. Int J Obes (Lond). 2022 Dec;46(12):2128-2136. doi: 10.1038/s41366-022-01224-x. Epub 2022 Sep 27. PMID: 36167764; PMCID: PMC9678795.