Synonym
LJ-2698; LJ2698; LJ 2698
IUPAC/Chemical Name
(2R,3R,4S)-2-(2-Chloro-4-((3-chlorobenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrothiophene-3,4-diol
InChi Key
BZESWLKPAGCGOS-XJKCOSOUSA-N
InChi Code
InChI=1S/C17H16Cl2N4O2S/c18-10-3-1-2-9(6-10)7-20-14-11-4-5-23(15(11)22-17(19)21-14)16-13(25)12(24)8-26-16/h1-6,12-13,16,24-25H,7-8H2,(H,20,21,22)/t12-,13-,16-/m1/s1
SMILES Code
O[C@H]1[C@H](N2C=CC3=C(NCC4=CC=CC(Cl)=C4)N=C(Cl)N=C32)SC[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
411.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Boo HJ, Park SJ, Noh M, Min HY, Jeong LS, Lee HY. LJ-2698, an Adenosine A3 Receptor Antagonist, Alleviates Elastase-Induced Pulmonary Emphysema in Mice. Biomol Ther (Seoul). 2020 May 1;28(3):250-258. doi: 10.4062/biomolther.2019.162. PMID: 32062956; PMCID: PMC7216744.
2. Dorotea D, Cho A, Lee G, Kwon G, Lee J, Sahu PK, Jeong LS, Cha DR, Ha H. Orally active, species-independent novel A3 adenosine receptor antagonist protects against kidney injury in db/db mice. Exp Mol Med. 2018 Apr 20;50(4):1-14. doi: 10.1038/s12276-018-0053-x. PMID: 29674631; PMCID: PMC5938017.
3. Lee JY, Park JH, Kim KT, Yu J, Sahu PK, Kang N, Shin HJ, Kim MH, Kim JS, Yoon IS, Jeong LS, Kim DD. Determination and validation of LJ-2698, a potent human A3 adenosine receptor antagonist, in rat plasma by liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic study. Arch Pharm Res. 2017 Aug;40(8):952-961. doi: 10.1007/s12272-017-0935-9. Epub 2017 Jul 29. PMID: 28756559.
