MedKoo Cat#: 130097 | Name: Synnepyrrole A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Synnepyrrole A is an anitbacterial agent whose mode of action has been characterized in Bacillus subtilis. Synnepyrrole A has been found to target the cytoplasmic membrane with evidence of protonophore activity occurring, and at higher concentrations, negatively has been shown to affect membrane function, allowing for normally membrane-impermeable dye molecules to pass through.

Chemical Structure

Synnepyrrole A
Synnepyrrole A
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130097

Name: Synnepyrrole A

CAS#: N/A

Chemical Formula: C17H27NO4

Exact Mass: 309.1940

Molecular Weight: 309.41

Elemental Analysis: C, 65.99; H, 8.80; N, 4.53; O, 20.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Synnepyrrole A
IUPAC/Chemical Name
2-(9-Methyldecyl)-1H-pyrrole-3,4-dicarboxylic acid
InChi Key
KTJTWTXWNLJBQT-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H27NO4/c1-12(2)9-7-5-3-4-6-8-10-14-15(17(21)22)13(11-18-14)16(19)20/h11-12,18H,3-10H2,1-2H3,(H,19,20)(H,21,22)
SMILES Code
O=C(C1=C(CCCCCCCCC(C)C)NC=C1C(O)=O)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Zhang L, Esquembre LA, Xia SN, Oesterhelt F, Hughes CC, Brötz-Oesterhelt H, Teufel R. Antibacterial Synnepyrroles from Human-Associated Nocardiopsis sp. Show Protonophore Activity and Disrupt the Bacterial Cytoplasmic Membrane. ACS Chem Biol. 2022 Oct 21;17(10):2836-2848. doi: 10.1021/acschembio.2c00460. Epub 2022 Sep 30. PMID: 36179367.