MedKoo Cat#: 130086 | Name: GW696155

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GW696155 is an inhibitor of the Schistosoma mansoni VKR2 Kinase Domain. SmVKR1 and SmVKR2 are vital for the growth of parasites and production of eggs, making them potential targets for treating schistosomiasis.

Chemical Structure

GW696155
GW696155
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130086

Name: GW696155

CAS#: N/A

Chemical Formula: C24H28N8O

Exact Mass: 444.2386

Molecular Weight: 444.54

Elemental Analysis: C, 64.85; H, 6.35; N, 25.21; O, 3.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GW696155
IUPAC/Chemical Name
4-(6-Isopropoxypyrazolo[1,5-b]pyridazin-3-yl)-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidin-2-amine
InChi Key
AJLPDJZYNSSQJO-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H28N8O/c1-17(2)33-23-9-8-22-20(16-26-32(22)29-23)21-10-11-25-24(28-21)27-18-4-6-19(7-5-18)31-14-12-30(3)13-15-31/h4-11,16-17H,12-15H2,1-3H3,(H,25,27,28)
SMILES Code
CN1CCN(C2=CC=C(NC3=NC=CC(C4=C5C=CC(OC(C)C)=NN5N=C4)=N3)C=C2)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Mathavan I, Liu LJ, Robinson SW, El-Sakkary N, Elatico AJJ, Gomez D, Nellas R, Owens RJ, Zuercher W, Navratilova I, Caffrey CR, Beis K. Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain. ACS Med Chem Lett. 2022 Oct 5;13(11):1715-1722. doi: 10.1021/acsmedchemlett.2c00248. PMID: 36385939; PMCID: PMC9661718.