CDD-1281 | CAS#3034215-91-0 | BMPR2 inhibitor

MedKoo Cat#: 122680 | Name: CDD-1281

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CDD-1281 is a potent and BMPR2-selective kinase inhibitor with IC50= 1.2nM. In vitro assays demonstrated that CDD-1281 effectively inhibits BMPR2 kinase activity, with an IC50 value in the low nanomolar range. Selectivity profiling revealed that CDD-1281 exhibits high specificity for BMPR2 over other kinases, minimizing potential off-target effects. Cell-based studies confirmed that CDD-1281 suppresses BMPR2-mediated signaling pathways, leading to decreased phosphorylation of downstream effectors.

Chemical Structure

CDD-1281

CAS#3034215-91-0

Theoretical Analysis

MedKoo Cat#: 122680

Name: CDD-1281

CAS#: 3034215-91-0

Chemical Formula: C30H27N5O2

Exact Mass: 489.2200

Molecular Weight: 489.58

Elemental Analysis: C, 73.60; H, 5.56; N, 14.31; O, 6.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CDD-1281; CDD1281; CDD 1281

IUPAC/Chemical Name

N-(3-carbamoylbenzyl)-1-cyclopentyl-2-(isoquinolin-6-yl)-1H-benzo[d]imidazole-6-carboxamide

InChi Key

KDAVHUIMGSUDCW-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H27N5O2/c31-28(36)21-5-3-4-19(14-21)17-33-30(37)23-10-11-26-27(16-23)35(25-6-1-2-7-25)29(34-26)22-8-9-24-18-32-13-12-20(24)15-22/h3-5,8-16,18,25H,1-2,6-7,17H2,(H2,31,36)(H,33,37)

SMILES Code

NC(C1=CC(CNC(C2=CC=C3C(N(C4CCCC4)C(C5=CC(C=CN=C6)=C6C=C5)=N3)=C2)=O)=CC=C1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

The discovery of monokinase-selective inhibitors for patients is challenging because the 500+ kinases encoded by the human genome share highly conserved catalytic domains. Until now, no selective inhibitors unique for a single transforming growth factor β (TGFβ) family transmembrane receptor kinase, including bone morphogenetic protein receptor type 2 (BMPR2), have been reported. This dearth of receptor-specific kinase inhibitors hinders therapeutic options for skeletal defects and cancer as a result of an overactivated BMP signaling pathway.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 489.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Jan 31. doi: 10.1021/acs.jmedchem.2c01886. Epub ahead of print. PMID: 36719862.