Tetrazanbigen | CAS#2121990-04-1 | Apoptosis Inducer

MedKoo Cat#: 565138 | Name: Tetrazanbigen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tetrazanbigen is an inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701.

Chemical Structure

Tetrazanbigen

CAS#2121990-04-1

Theoretical Analysis

MedKoo Cat#: 565138

Name: Tetrazanbigen

CAS#: 2121990-04-1

Chemical Formula: C18H16N4

Exact Mass: 288.1375

Molecular Weight: 288.35

Elemental Analysis: C, 74.98; H, 5.59; N, 19.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TNBG; Tetrazanbigen

IUPAC/Chemical Name

5,6,13,14-Tetrahydro-4bH-6,7,12,12b-tetraaza-benzo[b]chrysene

InChi Key

KQQCOPLSURIQAA-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16N4/c1-2-6-13-12(5-1)9-10-22-16(13)11-19-17-18(22)21-15-8-4-3-7-14(15)20-17/h1-8,16H,9-11H2,(H,19,20)

SMILES Code

C1(N=C2NCC34)=CC=CC=C1N=C2N4CCC5=C3C=CC=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 288.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zheng X, Li W, Lan Z, Yang X, Li L, Yuan Y, Xia Z, Chen X, Zhang X, Yu Y. Antitumour effects of tetrazanbigen against human hepatocellular carcinoma QGY-7701 through inducing lipid accumulation in vitro and in vivo. J Pharm Pharmacol. 2015 Nov;67(11):1593-602. doi: 10.1111/jphp.12467. Epub 2015 Aug 5. PubMed PMID: 26245909. 2: Yuan YH, Yang XL, Li W, Zheng XH, Gu R, Yu Y. [Subcellular proteomic analysis of Tetrazanbigen on human hepatocellular carcinoma cell line QGY-7701]. Zhonghua Gan Zang Bing Za Zhi. 2011 Dec;19(12):908-11. doi: 10.3760/cma.j.issn.1007-3418.2011.12.007. Chinese. PubMed PMID: 22525503. 3: Yuan Y, Li W, Li L, Yang X, Gu R, Liu H, Huang K, Yu Y. Effects of tetrazanbigen on the protein expression in human hepatocellular carcinoma cell line QGY-7701. J Huazhong Univ Sci Technolog Med Sci. 2009 Jun;29(3):304-8. doi: 10.1007/s11596-009-0308-9. Epub 2009 Jun 10. PubMed PMID: 19513611. 4: Yuan YH, Li W, Yang XL, Li LJ, Gu R, Tang WX, Yu Y. [Changes of protein expressions in human hepatocellular carcinoma cell line QGY-7701 induced by tetrazanbigen]. Zhonghua Gan Zang Bing Za Zhi. 2008 Jun;16(6):463-4. Chinese. PubMed PMID: 18579001.