Risvodetinib, also known as IkT-148009., is a brain-penetrant c-Abl inhibitor with a favorable toxicology profile. IkT-148009 suppressed c-Abl activation to baseline and substantially protected dopaminergic neurons from degeneration when administered therapeutically by once daily oral gavage beginning 4 weeks after disease initiation. Recovery of motor function in PD mice occurred within 8 weeks of initiating treatment concomitantly with a reduction in α-synuclein pathology in the mouse brain. IkT-148009 may have potential as a disease-modifying therapy in PD.
MedKoo Cat#: 130050
Name: Risvodetinib
CAS#: 2031185-00-7
Chemical Formula: C33H34N8O2
Exact Mass: 574.2805
Molecular Weight: 574.69
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 68.97; H, 5.96; N, 19.50; O, 5.57
The following data is based on the product molecular weight 574.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
