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MedKoo Cat#: 563000 | Name: LT175
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LT175 is a PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties.

Chemical Structure

LT175
LT175
CAS#862901-87-9

Theoretical Analysis

MedKoo Cat#: 563000

Name: LT175

CAS#: 862901-87-9

Chemical Formula: C21H18O3

Exact Mass: 318.1256

Molecular Weight: 318.37

Elemental Analysis: C, 79.23; H, 5.70; O, 15.08

Price and Availability

Size Price Availability Quantity
10mg USD 385.00 2 Weeks
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Related CAS #
No Data
Synonym
LT175; LT-175; LT 175;
IUPAC/Chemical Name
2(S)-(Biphenyl-4-yloxy)-3-phenyl-propionic acid
InChi Key
TZTPJJNNACUQQR-FQEVSTJZSA-N
InChi Code
InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1
SMILES Code
O=C(O)[C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ.
In vitro activity:
LT175 differentially activated PPARγ target genes involved in fatty acid esterification and storage in 3T3-L1-derived adipocytes. Reference: J Biol Chem. 2014 Mar 7;289(10):6908-6920. https://pubmed.ncbi.nlm.nih.gov/24451380/
In vivo activity:
Consistent with this hypothesis, in vivo administration of LT175 to mice fed a high-fat diet decreased body weight, adipocyte size, and white adipose tissue mass, as assessed by magnetic resonance imaging. Furthermore, LT175 significantly reduced plasma glucose, insulin, non-esterified fatty acids, triglycerides, and cholesterol and increased circulating adiponectin and fibroblast growth factor 21 levels. Reference: J Biol Chem. 2014 Mar 7;289(10):6908-6920. https://pubmed.ncbi.nlm.nih.gov/24451380/
Solvent mg/mL mM
Solubility
DMF 30.0 94.23
DMSO 50.0 157.05
DMSO:PBS (pH 7.2) (1:1) 0.5 1.57
Ethanol 25.0 78.52
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 318.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. PMID: 24451380; PMCID: PMC3945352.
In vitro protocol:
1. Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. PMID: 24451380; PMCID: PMC3945352.
In vivo protocol:
1. Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. PMID: 24451380; PMCID: PMC3945352.
1: Piemontese L, Fracchiolla G, Carrieri A, Parente M, Laghezza A, Carbonara G, Sblano S, Tauro M, Gilardi F, Tortorella P, Lavecchia A, Crestani M, Desvergne B, Loiodice F. Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor α/γ ligand LT175. Eur J Med Chem. 2015 Jan 27;90:583-94. doi: 10.1016/j.ejmech.2014.11.044. Epub 2014 Nov 24. PubMed PMID: 25497132. 2: Lori C, Pasquo A, Montanari R, Capelli D, Consalvi V, Chiaraluce R, Cervoni L, Loiodice F, Laghezza A, Aschi M, Giorgi A, Pochetti G. Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1965-76. doi: 10.1107/S1399004714009638. Epub 2014 Jun 29. PubMed PMID: 25004973. 3: Gilardi F, Giudici M, Mitro N, Maschi O, Guerrini U, Rando G, Maggi A, Cermenati G, Laghezza A, Loiodice F, Pochetti G, Lavecchia A, Caruso D, De Fabiani E, Bamberg K, Crestani M. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-20. doi: 10.1074/jbc.M113.506394. Epub 2014 Jan 22. PubMed PMID: 24451380; PubMed Central PMCID: PMC3945352. 4: Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. doi: 10.1021/jm800733h. PubMed PMID: 19053776.