MedKoo Cat#: 122572 | Name: CEE321
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CEE321 is a potent pan JAK inhibitor in enzyme and cellular assays (IC50 = 54 nM). CEE321 potently inhibited biomarkers relevant to atopic dermatitis.

Chemical Structure

CEE321
CEE321
CAS#2098545-89-0

Theoretical Analysis

MedKoo Cat#: 122572

Name: CEE321

CAS#: 2098545-89-0

Chemical Formula: C18H16ClN5O

Exact Mass: 353.1043

Molecular Weight: 353.81

Elemental Analysis: C, 61.11; H, 4.56; Cl, 10.02; N, 19.79; O, 4.52

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,350.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 5,950.00 2 Weeks
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Related CAS #
No Data
Synonym
CEE321; CEE-321; CEE 321
IUPAC/Chemical Name
4-((2-chlorophenyl)amino)-6-((6-methylpyridin-2-yl)amino)nicotinamide
InChi Key
OYWNKAAPXTYEBN-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H16ClN5O/c1-11-5-4-8-16(22-11)24-17-9-15(12(10-21-17)18(20)25)23-14-7-3-2-6-13(14)19/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)
SMILES Code
NC(C1=CN=C(NC2=NC(C)=CC=C2)C=C1NC3=CC=CC=C3Cl)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 353.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Thoma G, Duthaler RO, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, Orjuela Leon A, Viebrock S, Aichholz R, Beltz K, Grove K, Hoque S, Rudewicz PJ, Zerwes HG. Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis. J Med Chem. 2023 Jan 19. doi: 10.1021/acs.jmedchem.2c01977. Epub ahead of print. PMID: 36657024.