Synonym
SR120819A; SR 120819A; SR-120819A.
IUPAC/Chemical Name
(R)-N-((R)-3-(4-((Z)-N'-(((1s,4S)-4-((dimethylamino)methyl)cyclohexyl)methyl)carbamimidoyl)phenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-2-(naphthalene-2-sulfonamido)-3-phenylpropanamide
InChi Key
GKKPXBHNFVDHAQ-GWOGJWAKSA-N
InChi Code
InChI=1S/C43H54N6O4S/c1-48(2)30-34-16-14-33(15-17-34)29-45-41(44)36-20-18-32(19-21-36)27-40(43(51)49-24-8-9-25-49)46-42(50)39(26-31-10-4-3-5-11-31)47-54(52,53)38-23-22-35-12-6-7-13-37(35)28-38/h3-7,10-13,18-23,28,33-34,39-40,47H,8-9,14-17,24-27,29-30H2,1-2H3,(H2,44,45)(H,46,50)/t33-,34+,39-,40-/m1/s1
SMILES Code
O=C(N[C@H](CC1=CC=C(/C(N)=N/C[C@H]2CC[C@@H](CN(C)C)CC2)C=C1)C(N3CCCC3)=O)[C@H](NS(=O)(C4=CC=C5C=CC=CC5=C4)=O)CC6=CC=CC=C6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
751.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sjödin P, Holmberg SK, Akerberg H, Berglund MM, Mohell N, Larhammar D. Re-evaluation of receptor-ligand interactions of the human neuropeptide Y receptor Y1: a site-directed mutagenesis study. Biochem J. 2006 Jan 1;393(Pt 1):161-9. Erratum in: Biochem J. 2006 Sep 15;398(3):613. PubMed PMID: 16097949; PubMed Central PMCID: PMC1383674.
2: Holmberg SK, Mikko S, Boswell T, Zoorob R, Larhammar D. Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5. J Neurochem. 2002 May;81(3):462-71. PubMed PMID: 12065655.
3: Berglund MM, Lundell I, Cabrele C, Serradeil-Le Gal C, Beck-Sickinger AG, Larhammar D. Binding properties of three neuropeptide Y receptor subtypes from zebrafish: comparison with mammalian Y1 receptors. Biochem Pharmacol. 2000 Dec 15;60(12):1815-22. PubMed PMID: 11108796.
4: Serradeil-Le Gal C, Lafontan M, Raufaste D, Marchand J, Pouzet B, Casellas P, Pascal M, Maffrand JP, Le Fur G. Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes. FEBS Lett. 2000 Jun 16;475(2):150-6. PubMed PMID: 10858507.
5: Sun L, Philipson LH, Miller RJ. Regulation of K+ and Ca++ channels by a family of neuropeptide Y receptors. J Pharmacol Exp Ther. 1998 Feb;284(2):625-32. PubMed PMID: 9454807.
