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MedKoo Cat#: 130004 | Name: E11K4K10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E11K4K10 is an antimicrobial peptide against the antimicrobial-resistance crisis and has been shown to have an excellent therapeutic effect on a mouse model of pulmonary bacterial infection.

Chemical Structure

E11K4K10
E11K4K10
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130004

Name: E11K4K10

CAS#: N/A

Chemical Formula: C75H131N17O15

Exact Mass: 1510.0011

Molecular Weight: 1510.98

Elemental Analysis: C, 59.62; H, 8.74; N, 15.76; O, 15.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
E11K4K10;
IUPAC/Chemical Name
Phe-Leu-Pro-Lys-Val-Ala-Lys-Leu-Leu-Lys-Glu-Leu-Leu-NH2
InChi Key
ZSKCXPPAVFPFSQ-BQGXDPKVSA-N
InChi Code
InChI=1S/C75H131N17O15/c1-42(2)36-55(63(80)95)86-71(103)57(38-44(5)6)88-68(100)54(30-31-61(93)94)84-66(98)52(27-18-21-33-77)83-70(102)56(37-43(3)4)89-72(104)58(39-45(7)8)87-67(99)51(26-17-20-32-76)82-64(96)48(13)81-74(106)62(47(11)12)91-69(101)53(28-19-22-34-78)85-73(105)60-29-23-35-92(60)75(107)59(40-46(9)10)90-65(97)50(79)41-49-24-15-14-16-25-49/h14-16,24-25,42-48,50-60,62H,17-23,26-41,76-79H2,1-13H3,(H2,80,95)(H,81,106)(H,82,96)(H,83,102)(H,84,98)(H,85,105)(H,86,103)(H,87,99)(H,88,100)(H,89,104)(H,90,97)(H,91,101)(H,93,94)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,62-/m0/s1
SMILES Code
O=C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,510.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Ouyang X, Li B, Yang Y, Ba Z, Zhang J, Zhang T, Chang L, Zhang F, Zhang Y, Liu H, Gou S, Ni J. Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. J Med Chem. 2022 Oct 27;65(20):13833-13851. doi: 10.1021/acs.jmedchem.2c01076. Epub 2022 Sep 23. PMID: 36148510.