MedKoo Cat#: 206215 | Name: AZD-4769
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD-4769, also known as L 674573, is a leukotriene biosynthesis inhibitor.

Chemical Structure

AZD-4769
AZD-4769
CAS#127481-29-2 (free)

Theoretical Analysis

MedKoo Cat#: 206215

Name: AZD-4769

CAS#: 127481-29-2 (free)

Chemical Formula: C28H27NO3S

Exact Mass: 457.1712

Molecular Weight: 457.59

Elemental Analysis: C, 73.50; H, 5.95; N, 3.06; O, 10.49; S, 7.01

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,350.00 2 Weeks
200mg USD 2,350.00 2 Weeks
1g USD 4,850.00 2 Weeks
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Synonym
AZD4769; AZD-4769; AZD 4769; L 674573; L-674573; L674573; L-674,573; L 674,573; L674,573;
IUPAC/Chemical Name
2-((4-phenyl-1-(4-(quinolin-2-ylmethoxy)phenyl)butyl)thio)acetic acid
InChi Key
JOIXGLLMSDPZDN-UHFFFAOYSA-N
InChi Code
InChI=1S/C28H27NO3S/c30-28(31)20-33-27(12-6-9-21-7-2-1-3-8-21)23-14-17-25(18-15-23)32-19-24-16-13-22-10-4-5-11-26(22)29-24/h1-5,7-8,10-11,13-18,27H,6,9,12,19-20H2,(H,30,31)
SMILES Code
O=C(O)CSC(C1=CC=C(OCC2=NC3=CC=CC=C3C=C2)C=C1)CCCC4=CC=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
       

Preparing Stock Solutions

The following data is based on the product molecular weight 457.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
 1: Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PMID: 1538707. 2: Kargman S, Prasit P, Evans JF. Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. J Biol Chem. 1991 Dec 15;266(35):23745-52. PMID: 1748650.