DH4 is a SERT inhibitor with IC50 = 0.58 nM. DH4 was discovered with a bioavailability of 83.28% in rats by replacing the nonbioavailable substructure of approved drug vilazodone. DH4 exhibits promising antidepression efficacy in animal experiments.
MedKoo Cat#: 122519
Name: DH4
CAS#: N/A
Chemical Formula: C26H24F2N6
Exact Mass: 458.2000
Molecular Weight: 458.52
Elemental Analysis: C, 68.11; H, 5.28; F, 8.29; N, 18.33
The following data is based on the product molecular weight 458.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
