TDI-8414 | CAS# | Inhibitor | Antimalarial | Plasmodium Proteasome

MedKoo Cat#: 122508 | Name: TDI-8414

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TDI-8414 is an antimalarial Plasmodium Proteasome Inhibitor. TDI-8414 showed nanomolar antiparasitic activity, no toxicity to HepG2 cells, high selectivity against the Plasmodium proteasome over the human constitutive proteasome and immunoproteasome, improved solubility and PAMPA permeability, and enhanced metabolic stability in microsomes and plasma of both humans and mice.

Chemical Structure

TDI-8414

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 122508

Name: TDI-8414

CAS#: N/A

Chemical Formula: C34H45N5O7S

Exact Mass: 667.3040

Molecular Weight: 667.82

Elemental Analysis: C, 61.15; H, 6.79; N, 10.49; O, 16.77; S, 4.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

TDI-8414; TDI8414; TDI 8414

IUPAC/Chemical Name

(5S,8S,11S)-N-cyclopentyl-11-(1,1-dioxidoisothiazolidin-2-yl)-8-(2-morpholinoethyl)-7,10-dioxo-2-oxa-6,9-diaza-1,3(1,3)-dibenzenacyclododecaphane-5-carboxamide

InChi Key

OINUMUZFCZVWJP-CHQNGUEUSA-N

InChi Code

InChI=1S/C34H45N5O7S/c40-32-29(12-14-38-15-17-45-18-16-38)36-34(42)31(39-13-5-19-47(39,43)44)23-25-7-4-11-28(21-25)46-27-10-3-6-24(20-27)22-30(37-32)33(41)35-26-8-1-2-9-26/h3-4,6-7,10-11,20-21,26,29-31H,1-2,5,8-9,12-19,22-23H2,(H,35,41)(H,36,42)(H,37,40)/t29-,30-,31-/m0/s1

SMILES Code

O=C(N[C@@H](CCN1CCOCC1)C(N[C@@H](CC2=CC=CC(O3)=C2)C(NC4CCCC4)=O)=O)[C@H](CC5=CC3=CC=C5)N6CCCS6(=O)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 667.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K, Rosenthal PJ, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. J Med Chem. 2023 Jan 11. doi: 10.1021/acs.jmedchem.2c01651. Epub ahead of print. PMID: 36630286.