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MedKoo Cat#: 564901 | Name: LS10

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LS10 is a specific modulator of the action of ethanol at the large-conductance, calcium and voltage-activated potassium channel (BK channel).

Chemical Structure

LS10
LS10
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564901

Name: LS10

CAS#: NONE

Chemical Formula: C36H64N12O10S2

Exact Mass: 888.4310

Molecular Weight: 889.10

Elemental Analysis: C, 48.63; H, 7.26; N, 18.90; O, 17.99; S, 7.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CAVGRLAVC; LS-10; LS 10; LS10
IUPAC/Chemical Name
(4R,7S,10S,13S,16S,22S,25S,28R)-28-Amino-16-(3-guanidinopropyl)-13-isobutyl-7,22-diisopropyl-10,25-dimethyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxylic acid
InChi Key
CGLUMGXXJAFEMO-WOUSRVCJSA-N
InChi Code
InChI=1S/C36H64N12O10S2/c1-16(2)12-23-32(54)43-20(8)29(51)48-27(18(5)6)34(56)46-24(35(57)58)15-60-59-14-21(37)30(52)42-19(7)28(50)47-26(17(3)4)33(55)41-13-25(49)44-22(31(53)45-23)10-9-11-40-36(38)39/h16-24,26-27H,9-15,37H2,1-8H3,(H,41,55)(H,42,52)(H,43,54)(H,44,49)(H,45,53)(H,46,56)(H,47,50)(H,48,51)(H,57,58)(H4,38,39,40)/t19-,20-,21-,22-,23-,24-,26-,27-/m0/s1
SMILES Code
O=C([C@@H](NC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC([C@H](C)N1)=O)=O)=O)=O)=O)=O)=O)CSSC[C@H](N)C1=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 889.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Scott LL, Iyer S, Philpo AE, Avalos MN, Wu NS, Shi T, Prakash BA, Nguyen TT, Mihic SJ, Aldrich RW, Pierce JT. A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo. J Pharmacol Exp Ther. 2018 Nov;367(2):282-290. doi: 10.1124/jpet.118.251918. Epub 2018 Aug 29. PubMed PMID: 30158242; PubMed Central PMCID: PMC6178125.