Synonym
5-Fluorouridine; 5-Fur Uridine, 5-fluoro-; fluorouridine; Flosfluridine tidoxil
IUPAC/Chemical Name
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidine-2,4(1H,3H)-dione
InChi Key
FHIDNBAQOFJWCA-UAKXSSHOSA-N
InChi Code
InChI=1S/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
SMILES Code
O=C1NC(C(F)=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
262.19
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5-fluorouracil in an experimental model for the treatment of vitreoretinal
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Huitema ADR, Dorlo TPC. Population Pharmacokinetics of Intracellular
5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome
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PMID: 24130026.
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Engels SAG, Hofman DA, Öhlin S, Meineke B, Bykov VJN, van Heesch S, Wiman KG.
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5-Fluorouridine. Cell Death Dis. 2022 Nov 25;13(11):997. doi:
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7: Mori H, Sakamoto O, Kitaichi K, Koda A, Kita J. Novel derivatives of
5-fluorouridine and 5-fluorouracil having potent antitumor and lower
immunosuppressive activities. Jpn J Pharmacol. 1992 Mar;58(3):269-82. doi:
10.1254/jjp.58.269. PMID: 1513076.
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