ACBI1 is a potent and cooperative degrader of SMARCA2, SMARCA4 and PBRM1, genes whose associated proteins alter chromatin structure. ACBI1 induced anti-proliferative effects and cell death caused by SMARCA2 depletion in SMARCA4 mutant cancer cells, and in acute myeloid leukemia cells dependent on SMARCA4 ATPase activity. ACBI1 is an example of a successful biophysics- and structure-based PROTAC design approach to degrade high profile drug targets, ands pave the way toward new therapeutics for the treatment of tumors sensitive to the loss of BAF complex ATPases.
MedKoo Cat#: 556161
Name: ACBI1
CAS#: 2375564-55-7 (free base)
Chemical Formula: C49H58FN9O7S
Exact Mass: 935.4164
Molecular Weight: 936.12
Elemental Analysis: C, 62.87; H, 6.25; F, 2.03; N, 13.47; O, 11.96; S, 3.42
The following data is based on the product molecular weight 936.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
