GVN00818, also known as (S,R,S)-VL285 Phenol-C3-piperazine hydrochloride, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand with alternative exit vector from the widely used VH032, a linker with added rigidity, and a pendant amine for reactivity with a carboxylic acid on the target ligand. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate ProTAC librarires that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 121229
Name: GVN00818
CAS#: Unknown
Chemical Formula: C42H52ClN7O6S
Exact Mass: 817.3388
Molecular Weight: 818.43
Elemental Analysis: C, 61.64; H, 6.40; Cl, 4.33; N, 11.98; O, 11.73; S, 3.92
The following data is based on the product molecular weight 818.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
