TAI-1 | CAS# 1334921-03-7 | Hec1 Inhibitor

MedKoo Cat#: 565020 | Name: TAI-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TAI-1 is a potent first-in-class Hec1 inhibitor, as well as an anti-cancer agent.

Chemical Structure

TAI-1

CAS#1334921-03-7

Theoretical Analysis

MedKoo Cat#: 565020

Name: TAI-1

CAS#: 1334921-03-7

Chemical Formula: C24H21N3O3S

Exact Mass: 431.1304

Molecular Weight: 431.51

Elemental Analysis: C, 66.80; H, 4.91; N, 9.74; O, 11.12; S, 7.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TAI1; TAI 1; TAI-1

IUPAC/Chemical Name

N-[4-[4-(4-Methoxyphenoxy)-2,6-dimethylphenyl]-2-thiazolyl]-4-pyridinecarboxamide

InChi Key

NBNNDUZYMXBCOX-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H21N3O3S/c1-15-12-20(30-19-6-4-18(29-3)5-7-19)13-16(2)22(15)21-14-31-24(26-21)27-23(28)17-8-10-25-11-9-17/h4-14H,1-3H3,(H,26,27,28)

SMILES Code

O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(OC4=CC=C(OC)C=C4)C=C3C)=CS2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 431.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang LY, Lee YS, Huang JJ, Chang CC, Chang JM, Chuang SH, Kao KJ, Tsai YJ, Tsai PY, Liu CW, Lin HS, Lau JY. Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1. J Exp Clin Cancer Res. 2014 Jan 9;33:6. doi: 10.1186/1756-9966-33-6. PubMed PMID: 24401611; PubMed Central PMCID: PMC3895848. 2: Nishida H, Endo K, Hatano M, Tatekawa N, Mashima E, Hashida R, Hori M, Obara K. [Isolated central nervous system relapse in type II enteropathy-associated T cell lymphoma]. Rinsho Ketsueki. 2015 Jun;56(6):692-8. doi: 10.11406/rinketsu.56.692. Japanese. PubMed PMID: 26256881.