BLU2864 is a potent and highly selective PRKACA inhibitor. And, it shows potential for fibrolamellar carcinoma research, BLU2864. BLU2864 inhibits PRKACA kinase with an IC50 of 0.3 nM. Additionally, BLU2864 shows anti-tumor activity. BLU2864 can be used in cancer and polycystic kidney disease research. In mIMCD3 cells, BLU2864 (40 nM and 200 nM; 5 d) inhibits forskolin-induced in vitro cystogenesis of mIMCD3 cells cultured in Matrigel by 72% and 100% at 40 and 200 nM concentrations, respectively. Additionally, BLU2864 inhibits ex vivo p-Ser133 CREB expression and cystogenesis.
MedKoo Cat#: 408183
Name: BLU-2864
CAS#: 2810747-89-6
Chemical Formula: C24H19F3N4O2
Exact Mass: 452.1460
Molecular Weight: 452.44
Elemental Analysis: C, 63.71; H, 4.23; F, 12.60; N, 12.38; O, 7.07
The following data is based on the product molecular weight 452.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
