Diethazine (free base) | CAS# 60-91-3 (free base) | anti-Parkinson

MedKoo Cat#: 412421 | Name: Diethazine (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethazine (free base) is a phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor.

Chemical Structure

Diethazine (free base)

CAS#60-91-3 (free base)

Theoretical Analysis

MedKoo Cat#: 412421

Name: Diethazine (free base)

CAS#: 60-91-3 (free base)

Chemical Formula: C18H22N2S

Exact Mass: 298.1504

Molecular Weight: 298.45

Elemental Analysis: C, 72.44; H, 7.43; N, 9.39; S, 10.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

341-70-8 (HCl) 60-91-3 (free base)

Synonym

Diethazine (free base); EINECS 200-491-3; Dolisina; Lodibon; Casantin

IUPAC/Chemical Name

N,N-diethyl-2-(10H-phenothiazin-10-yl)ethan-1-amine

InChi Key

LURMIKVZJSMXQE-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H22N2S/c1-3-19(4-2)13-14-20-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)20/h5-12H,3-4,13-14H2,1-2H3

SMILES Code

CCN(CC)CCN1C2=C(C=CC=C2)SC3=CC=CC=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 298.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hornyak I, Kozma L, Lapat A, Tovari I. Spectrofluorimetric determination of diethazine and promethazine in pharmaceutical preparations. Biomed Chromatogr. 1997 Mar-Apr;11(2):99-101. doi: 10.1002/(SICI)1099-0801(199703)11:2<99::AID- BMC658>3.0.CO;2-W. PMID: 9137772. 2: Rychlovský P, Nemcová I. The effect of surfactants on the dissociation constants of phenothiazine derivatives Alkalimetric determination of diethazine and chlorpromazine. Talanta. 1988 Mar;35(3):211-4. doi: 10.1016/0039-9140(88)80067-5. PMID: 18964497. 3: DAVIS RA, KAUL CL, LOCKETT MF. A note on the influence of chlorpromazine and diethazine on the stores of catecholamine in the adrenal glands and aortic walls of rats. J Pharm Pharmacol. 1962 Nov;14:735-8. doi: 10.1111/j.2042-7158.1962.tb11168.x. PMID: 14025511. 4: Puzanowska-Tarasiewicz H, Tarasiewicz M, Grudniewska A. Use of diethazine hydrochloride for the extractive spectrophotometric determination of uranium and as a redox indicator. Talanta. 1977 Oct;24(10):609-12. doi: 10.1016/0039-9140(77)80104-5. PMID: 18962157. 5: HELLER GC, SIME DA. Agranulocytosis during treatment with diethazine hydrochloride. Lancet. 1952 Jan 26;1(6700):192-3. doi: 10.1016/s0140-6736(52)91413-x. PMID: 14889809. 6: Gowda HS, Ramappa PG. Rapid spectrophotometric determination of ruthenium with diethazine hydrochloride. Talanta. 1976 Jul;23(7):552. doi: 10.1016/0039-9140(76)80157-9. PMID: 18961923. 7: Rump S, Edelwejn Z. Investigations on the effects of diethazine on neuromuscular transmission in the rat. Acta Physiol Pol. 1973 Nov- Dec;24(6):883-6. PMID: 4358187. 8: CREYSSEL J, DE MOURGUES G, DELEUZE R, CHATELAIN ML. INT'ER ET DE L'ASSOCIATION DIETHAZINE. P'ETHIDINE (DIPARCOL-DOLOSAL) HYDROXYDIONE (VIADRIL) DANS L'ANESTH'ESIE G'EN'ERALE DES MALADES AG'ES OU DES VIEILLARDS EN TRAUMATOLOGIE [IMPORTANCE OF DIETHAZINE COMBINATIONS. PETHIDINE (DIPARCOL- DOLOSAL) HYDROXYDIONE (VIADRIL) IN GENERAL ANESTHESIA IN AGED PATIENTS OR IN THE ELDERLY IN TRAUMATOLOGY]. Lyon Chir. 1964 Jul;60:540-4. French. PMID: 14208266. 9: BONAFOS M, GRASSET D, BADOSA, STOEBER M. L'ANESTH'ESIE G'EN'ERALE EN CHIRURGIE UROLOGIQUE CHEZ LE VIEILLARD. INT'ER ET DE L'ASSOCIATION HYDROXYDIONE-P'ETHIDINE-DI'ETHAZINE [GENERAL ANESTHESIA IN UROLOGIC SURGERY IN THE AGED. VALUE OF THE HYDROXYDIONE-PETHIDINE-DIETHAZINE]. Anesth Analg (Paris). 1964 Jul-Sep;21:421-9. French. PMID: 14180374. 10: SILVESTRINI B, MAFFII G. Effects of chlorpromazine, promazine, diethazine, reserpine, hydroxyzine, and morphine upon some mono- and polysynaptic motor reflexes. J Pharm Pharmacol. 1959 Apr;11(4):224-33. doi: 10.1111/j.2042-7158.1959.tb12548.x. PMID: 13642294.