MMN05559, also known as (S,R,S)-AHPC-C6-PEG3-butyl chloride, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on the target ligand. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 121183
Name: MMN05559
CAS#: 1835705-55-9
Chemical Formula: C38H59ClN4O7S
Exact Mass: 750.3793
Molecular Weight: 751.42
Elemental Analysis: C, 60.74; H, 7.91; Cl, 4.72; N, 7.46; O, 14.90; S, 4.27
The following data is based on the product molecular weight 751.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
