Synonym
Aspartyllysine; Asp-lys;
IUPAC/Chemical Name
N6-((S)-3-amino-3-carboxypropanoyl)-L-lysine
InChi Key
VNJVIQOAVBMTIB-BQBZGAKWSA-N
InChi Code
InChI=1S/C10H19N3O5/c11-6(9(15)16)3-1-2-4-13-8(14)5-7(12)10(17)18/h6-7H,1-5,11-12H2,(H,13,14)(H,15,16)(H,17,18)/t6-,7-/m0/s1
SMILES Code
N[C@@H](CCCCNC(C[C@@H](C(O)=O)N)=O)C(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
261.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tobey NA, Lyn-Cook LE, Ulshen MH, Heizer WD. Intestinal brush border peptidases: activities in normal and abnormal peroral intestinal biopsy specimens. J Lab Clin Med. 1986 Mar;107(3):221-7. PubMed PMID: 2869093.
2: Liu JM, Garcia-Alvarez MC, Bignon J, Kusinski M, Kuzdak K, Riches A, Wdzieczak-Bakala J. Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases. Ann N Y Acad Sci. 2010 Apr;1194:53-9. doi: 10.1111/j.1749-6632.2010.05488.x. Review. PubMed PMID: 20536450.
3: Dubos F, Pelissier JP, Andrieux C, Ducluzeau R, Raibaud P. Inhibitory effect of a copper-dipeptide complex on the establishment of a Clostridium perenne strain in the intestinal tract of gnotobiotic mice. Appl Environ Microbiol. 1985 Nov;50(5):1258-61. PubMed PMID: 4091557; PubMed Central PMCID: PMC238735.
4: Bagriantseva OV, Kalamkarova LI, Rokutova AV, Aznametova GK, Idrisova RS. [The diagnosis of intestinal dysbacteriosis by the spectrum of fecal amino acids]. Zh Mikrobiol Epidemiol Immunobiol. 1999 Jul-Aug;(4):67-9. Russian. PubMed PMID: 10852057.
5: Klostermeyer H. N epsilon-(beta-aspartyl)lysine. Methods Enzymol. 1984;107:258-61. PubMed PMID: 6503713.
6: SWALLOW DL, LOCKHART IM, ABRAHAM EP. Synthesis of epsilon-aspartyllysines and of isohexylamides of aspartic acid. Biochem J. 1958 Nov;70(3):359-64. PubMed PMID: 13596351; PubMed Central PMCID: PMC1196682.
7: Belokrylov GA, Derevinina ON, Popova OI, Molchanova IV, Sorochinskaia EI. [Differences in immune response, phagocytosis and detoxifying properties due to effect of peptide and amino acid preparations]. Biull Eksp Biol Med. 1996 May;121(5):509-12. Russian. PubMed PMID: 8744123.
8: Pélissier JP, Dubos F. beta-Aspartyl-epsilon-lysine, a peptide of the fecal contents of axenic mice. Reprod Nutr Dev. 1983;23(3):509-15. PubMed PMID: 6612090.
9: Oizumi J, Hayakawa K. Lipoamidase (lipoyl-X hydrolase) from pig brain. Biochem J. 1990 Mar 1;266(2):427-34. PubMed PMID: 2317196; PubMed Central PMCID: PMC1131149.
10: Tobey N, Heizer W, Yeh R, Huang TI, Hoffner C. Human intestinal brush border peptidases. Gastroenterology. 1985 Apr;88(4):913-26. PubMed PMID: 3882510.
11: Hurrell RF, Carpenter KJ. Nutritional significance of cross-link formation during food processing. Adv Exp Med Biol. 1977;86B:225-38. PubMed PMID: 906918.