IUPAC/Chemical Name
Quinoline, 2-phenyl-4-(2-(3-piperidinyl)ethyl)-
InChi Key
BRSGIGKMAFNWJD-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H24N2/c1-2-8-18(9-3-1)22-15-19(13-12-17-7-6-14-23-16-17)20-10-4-5-11-21(20)24-22/h1-5,8-11,15,17,23H,6-7,12-14,16H2
SMILES Code
C1(C2=CC=CC=C2)=NC3=CC=CC=C3C(CCC4CNCCC4)=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
316.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: File SE. Sedative effects of PK 9084 and PK 8165, alone and in combination with chlordiazepoxide. Br J Pharmacol. 1983 May;79(1):219-23. doi: 10.1111/j.1476-5381.1983.tb10515.x. PMID: 6871544; PMCID: PMC2044829.
2: Gee KW. Phenylquinolines PK 8165 and PK 9084 allosterically modulate [35S]t-butylbicyclophosphorothionate binding to a chloride ionophore in rat brain via a novel Ro5 4864 binding site. J Pharmacol Exp Ther. 1987 Mar;240(3):747-53. PMID: 3031273.
3: Keane PE, Simiand J, Morre M. The quinolines PK 8165 and PK 9084 possess benzodiazepine-like activity in vitro but not in vivo. Neurosci Lett. 1984 Mar 9;45(1):89-93. doi: 10.1016/0304-3940(84)90334-3. PMID: 6145125.
4: File SE, Lister RG. Quinolines and anxiety: anxiogenic effects of CGS 8216 and partial anxiolytic profile of PK 9084. Pharmacol Biochem Behav. 1983 Feb;18(2):185-8. doi: 10.1016/0091-3057(83)90361-1. PMID: 6132404.
5: File SE, Pellow S. The effects of putative anxiolytic compounds (PK 8165, PK 9084 and tracazolate) on the rat corticosterone response. Physiol Behav. 1985 Oct;35(4):583-6. doi: 10.1016/0031-9384(85)90144-1. PMID: 2866553.
6: Gee KW, Brinton RE, Yamamura HI. PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam. Brain Res. 1983 Mar 28;264(1):168-72. doi: 10.1016/0006-8993(83)91138-1. PMID: 6303496.
7: File SE, Wilks L. Effects of acute and chronic treatment on the pro- and anti-convulsant actions of CL 218, 872, PK 8165 and PK 9084, putative ligands for the benzodiazepine receptor. J Pharm Pharmacol. 1985 Apr;37(4):252-6. doi: 10.1111/j.2042-7158.1985.tb05054.x. PMID: 2860223.
8: Le Fur G, Mizoule J, Burgevin MC, Ferris O, Heaulme M, Gauthier A, Guérémy C, Uzan A. Multiple benzodiazepine receptors: evidence of dissociation between anticonflict and anticonvulsant properties by PK 8165 and PK 9084 (two quinoline derivatives). Life Sci. 1981 Mar 30;28(13):1439-48. doi: 10.1016/0024-3205(81)90375-1. PMID: 6264247.
9: Broekkamp CL, Le Pichon M, Lloyd KG. The comparative effects of benzodiazepines, progabide and PK 9084 on acquisition of passive avoidance in mice. Psychopharmacology (Berl). 1984;83(1):122-5. doi: 10.1007/BF00427435. PMID: 6429696.
10: File SE, Simmonds MA. Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro. Eur J Pharmacol. 1984 Jan 27;97(3-4):295-300. doi: 10.1016/0014-2999(84)90463-1. PMID: 6705827.
