MedKoo Cat#: 318750 | Name: Spaglumic Acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Spaglumic Acid is a peptide neurotransmitter and the third-most-prevalent neurotransmitter in the mammalian nervous system. NAAG consists of N-acetylaspartic acid (NAA) and glutamic acid coupled via a peptide bond.

Chemical Structure

Spaglumic Acid
Spaglumic Acid
CAS#4910-46-7

Theoretical Analysis

MedKoo Cat#: 318750

Name: Spaglumic Acid

CAS#: 4910-46-7

Chemical Formula: C11H18N2O10

Exact Mass: 338.0961

Molecular Weight: 338.27

Elemental Analysis: C, 39.06; H, 5.36; N, 8.28; O, 47.30

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Related CAS #
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Synonym
Spaglumic Acid; Naaxia
IUPAC/Chemical Name
(S)-1-(((S)-3-acetamido-3-(carboxyoxy)propyl)amino)propane-1,3-diyl bis(hydrogen carbonate)
InChi Key
SEXITTMZKJJBAE-YUMQZZPRSA-N
InChi Code
InChI=1S/C11H18N2O10/c1-6(14)13-8(23-11(19)20)2-4-12-7(22-10(17)18)3-5-21-9(15)16/h7-8,12H,2-5H2,1H3,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/t7-,8-/m0/s1
SMILES Code
CC(N[C@@H](OC(O)=O)CCN[C@@H](OC(O)=O)CCOC(O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sanchis-Merino ME, Montero JA, Ruiz-Moreno JM, Rodriguez AE, Pastor S. Comparative efficacy of topical antihistamines in an animal model of early phase allergic conjunctivitis. Exp Eye Res. 2008 May;86(5):791-7. doi: 10.1016/j.exer.2008.02.007. Epub 2008 Mar 4. PubMed PMID: 18378229. 2: Purello D'Ambrosio F, Gangemi S, Ricciardi L, Cuzzocrea S, Di Lorenzo G. Lodoxamide versus spaglumic acid: a comparative double-blind trial on patients suffering from seasonal allergic conjunctivitis induced by Parietaria pollen. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):233-7. PubMed PMID: 9395007. 3: Reddy AV, Ravindranath B. Synthesis of alpha-, beta- and cyclic spaglumic acids. Int J Pept Protein Res. 1992 Nov;40(5):472-6. PubMed PMID: 1362393.