MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 208453 | Name: ACHP HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ACHP is an IκB kinase inhibitor that inhibits DNA binding activity of NF-κB, blocks NF-κB pathway in multiple myeloma cell lines, and induces cell growth arrest and apoptosis. It also inhibits STAT3 signaling in NSCLC in vitro.

Chemical Structure

ACHP HCl
ACHP HCl
CAS#406209-26-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 208453

Name: ACHP HCl

CAS#: 406209-26-5 (HCl)

Chemical Formula: C21H25ClN4O2

Exact Mass: 400.1666

Molecular Weight: 400.91

Elemental Analysis: C, 62.92; H, 6.29; Cl, 8.84; N, 13.98; O, 7.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
406208-42-2 (free base) 406209-26-5 (HCl)
Synonym
IKK-2 Inhibitor VIII; ACHP HCl; ACHP hydrochloride
IUPAC/Chemical Name
2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-piperidin-4-ylpyridine-3-carbonitrilen hydrochloride
InChi Key
QVYAMWAKDKEKMM-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24N4O2.ClH/c22-11-16-15(14-6-8-24-9-7-14)10-17(25-21(16)23)20-18(26)2-1-3-19(20)27-12-13-4-5-13;/h1-3,10,13-14,24,26H,4-9,12H2,(H2,23,25);1H
SMILES Code
OC1=C(C2=CC(C3CCNCC3)=C(C#N)C(N)=N2)C(OCC4CC4)=CC=C1.Cl
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 400.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shen L, Xiao Y, Xie H, Zhao H, Luo T, Liu L, Pan X. A naturally derived small molecule NDSM253 inhibits IKK1 to suppress inflammation response and promote bone healing after fracture. Am J Transl Res. 2021 Jan 15;13(1):24-37. PMID: 33527006; PMCID: PMC7847520. 2: Mitrokhin V, Gorbacheva L, Vachrushev N, Hadzi-Petrushev N, Kamkin A, Mladenov M. Cardiomyocytes' prolonged IL-2 incubation induces enhancement in L-type Ca2+ channels mediated by inhibitory-kappaB kinase/nuclear factor-kappaB signalling. Basic Clin Pharmacol Toxicol. 2021 Feb;128(2):234-240. doi: 10.1111/bcpt.13491. Epub 2020 Oct 2. PMID: 32946663. 3: Millen S, Meretuk L, Göttlicher T, Schmitt S, Fleckenstein B, Thoma-Kress AK. A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells. Retrovirology. 2020 Sep 10;17(1):30. doi: 10.1186/s12977-020-00538-w. PMID: 32912211; PMCID: PMC7488018. 4: Li L, Cataisson C, Flowers B, Fraser E, Sanchez V, Day CP, Yuspa SH. Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin. J Invest Dermatol. 2019 Jul;139(7):1506-1515.e7. doi: 10.1016/j.jid.2018.12.026. Epub 2019 Jan 23. PMID: 30684549; PMCID: PMC6591043. 5: Li M, Zhao J, Jia L. USP14-mediated IκBα degradation exacerbates NF-κB activation and IL-1β-stimulated chondrocyte dedifferentiation. Life Sci. 2019 Feb 1;218:147-152. doi: 10.1016/j.lfs.2018.12.014. Epub 2018 Dec 11. PMID: 30550885. 6: Du J, He Y, Li P, Wu W, Chen Y, Ruan H. IL-8 regulates the doxorubicin resistance of colorectal cancer cells via modulation of multidrug resistance 1 (MDR1). Cancer Chemother Pharmacol. 2018 Jun;81(6):1111-1119. doi: 10.1007/s00280-018-3584-x. Epub 2018 Apr 24. PMID: 29693201. 7: Wang GJ, Shen NJ, Cheng L, Yehan Fang, Huang H, Li KH. Visfatin triggers the in vitro migration of osteosarcoma cells via activation of NF-κB/IL-6 signals. Eur J Pharmacol. 2016 Nov 15;791:322-330. doi: 10.1016/j.ejphar.2016.08.029. Epub 2016 Aug 26. PMID: 27568842. 8: Feist M, Kemper J, Taruttis F, Rehberg T, Engelmann JC, Gronwald W, Hummel M, Spang R, Kube D. Synergy of interleukin 10 and toll-like receptor 9 signalling in B cell proliferation: Implications for lymphoma pathogenesis. Int J Cancer. 2017 Mar 1;140(5):1147-1158. doi: 10.1002/ijc.30444. Epub 2016 Oct 17. PMID: 27668411. 9: Wang G, Tian W, Liu Y, Ju Y, Shen Y, Zhao S, Zhang B, Li Y. Visfatin Triggers the Cell Motility of Non-Small Cell Lung Cancer via Up-Regulation of Matrix Metalloproteinases. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):548-554. doi: 10.1111/bcpt.12623. Epub 2016 Jul 21. PMID: 27224551. 10: Zhu G, Huang Y, Wu C, Wei D, Shi Y. Activation of G-Protein-Coupled Estrogen Receptor Inhibits the Migration of Human Nonsmall Cell Lung Cancer Cells via IKK-β/NF-κB Signals. DNA Cell Biol. 2016 Aug;35(8):434-42. doi: 10.1089/dna.2016.3235. Epub 2016 Apr 15. PMID: 27082459.