P163-0892 | CAS# 1574576-45-6 | Antifungal agent

MedKoo Cat#: 121042 | Name: P163-0892

Description:

WARNING: This product is for research use only, not for human or veterinary use.

P163-0892 is an antifungal agent. P163-0892 had potent in vitro and in vivo antifungal activity against Cryptococcus spp. In vitro tests showed that P163-0892 was not cytotoxic and had highly selective and strong antifungal activities against Cryptococcus spp. with MIC values less than 1 μg/mL.

Chemical Structure

P163-0892

CAS#1574576-45-6

Theoretical Analysis

MedKoo Cat#: 121042

Name: P163-0892

CAS#: 1574576-45-6

Chemical Formula: C19H20N2O3S

Exact Mass: 356.1195

Molecular Weight: 356.44

Elemental Analysis: C, 64.02; H, 5.66; N, 7.86; O, 13.47; S, 8.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

P163-0892; P163 0892; P1630892

IUPAC/Chemical Name

4-benzyl-N-butyl-7-hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide

InChi Key

HURDGGGKSYBXNL-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20N2O3S/c1-2-3-10-20-18(23)15-16(22)17-14(9-11-25-17)21(19(15)24)12-13-7-5-4-6-8-13/h4-9,11,22H,2-3,10,12H2,1H3,(H,20,23)

SMILES Code

OC(C(SC=C1)=C1N2CC3=CC=CC=C3)=C(C(NCCCC)=O)C2=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 356.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Li L, Wu H, Zhu S, Ji Z, Chi X, Xie F, Hao Y, Lu H, Yang F, Yan L, Zhang D, Jiang Y, Ni T. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J Med Chem. 2022 Aug 25;65(16):11257-11269. doi: 10.1021/acs.jmedchem.2c00794. Epub 2022 Aug 3. PMID: 35922963.