SPH3127 is a Highly Potent, and Orally Active Direct Renin Inhibitor. SPH3127 demonstrated higher bioavailability and a more potent antihypertensive effect in preclinical models than aliskiren and has completed a phase II clinical trial for essential hypertension.
MedKoo Cat#: 121038
Name: SPH3127
CAS#: 1399849-02-5 (free base)
Chemical Formula: C22H32N6O4
Exact Mass: 444.2485
Molecular Weight: 444.54
Elemental Analysis: C, 59.44; H, 7.26; N, 18.91; O, 14.40
The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
