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MedKoo Cat#: 112199 | Name: Ziyuglycoside I
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ziyuglycoside I increases the synthesis of type I collagen in CCD-1064Sk human fibroblast cells and inhibits the proliferation of MDA-MB-231 breast cancer cells.

Chemical Structure

Ziyuglycoside I
Ziyuglycoside I
CAS#35286-58-9

Theoretical Analysis

MedKoo Cat#: 112199

Name: Ziyuglycoside I

CAS#: 35286-58-9

Chemical Formula: C41H66O13

Exact Mass: 766.4503

Molecular Weight: 766.97

Elemental Analysis: C, 64.21; H, 8.67; O, 27.12

Price and Availability

Size Price Availability Quantity
1mg USD 260.00 2 Weeks
5mg USD 660.00 2 Weeks
10mg USD 1,000.00 2 Weeks
25mg USD 1,710.00 2 Weeks
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Related CAS #
No Data
Synonym
Gouguside 7, Ziyuglycoside I
IUPAC/Chemical Name
(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl (1R,2R,4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-(((2S,3R,4S,5S)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate
InChi Key
WCHBFWOEFOZHMK-MLHVESHNSA-N
InChi Code
InChI=1S/C41H66O13/c1-20-10-15-41(35(49)54-34-31(48)29(46)28(45)23(18-42)52-34)17-16-38(5)21(32(41)40(20,7)50)8-9-25-37(4)13-12-26(36(2,3)24(37)11-14-39(25,38)6)53-33-30(47)27(44)22(43)19-51-33/h8,20,22-34,42-48,50H,9-19H2,1-7H3/t20-,22+,23-,24+,25-,26+,27+,28-,29+,30-,31-,32-,33+,34+,37+,38-,39-,40-,41+/m1/s1
SMILES Code
OC[C@@H](O[C@H]1OC([C@@]23[C@]([H])(C4=CC[C@]5([H])[C@]6(C)[C@@]([H])(CC[C@]5([C@]4(C)CC3)C)C([C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O)CO7)CC6)(C)C)[C@]([C@H](C)CC2)(C)O)=O)[C@@H](O)[C@H](O)[C@H]1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 10.0 13.04
DMSO 5.0 6.52
Ethanol 5.0 6.52
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 766.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Long J, Lai H, Huang Y, You F, Jiang Y, Kuang Q. Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products. Pharmacol Res. 2025 Jan 6;212:107589. doi: 10.1016/j.phrs.2025.107589. Epub ahead of print. PMID: 39778641. 2: Shen X, Wang Z, Li W, Mei S, Ma S, Wang X, Wen C, Chen F, Zheng G. Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC- MS/MS. Int J Anal Chem. 2024 Mar 1;2024:7971021. doi: 10.1155/2024/7971021. PMID: 38463657; PMCID: PMC10923622. 3: Wang H, Chen L, Li R, Lv C, Xu Y, Xiong Y. Polydopamine-coated mesoporous silica nanoparticles co-loaded with Ziyuglycoside I and Oseltamivir for synergistic treatment of viral pneumonia. Int J Pharm. 2023 Oct 15;645:123412. doi: 10.1016/j.ijpharm.2023.123412. Epub 2023 Sep 12. PMID: 37703956. 4: Lim JW, Seo JK, Jung SJ, Lee KY, Kang SY. An antiviral optimized extract from Sanguisorba officinalis L. roots using response surface methodology, and its efficacy in controlling viral hemorrhagic septicemia of olive flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 2023 Oct;141:109066. doi: 10.1016/j.fsi.2023.109066. Epub 2023 Sep 7. PMID: 37689225. 5: Li Y, Tian YY, Wang J, Lin R, Zhang Y, Zhang MM, Dong TW, Li M, Xie YH, Zheng XH, Yang Q, Yuan JN, Si-Wang W. Main active components of Ilex rotunda Thunb. protect against ulcerative colitis by restoring the intestinal mucosal barrier and modulating the cytokine-cytokine interaction pathways. J Ethnopharmacol. 2024 Jan 10;318(Pt B):116961. doi: 10.1016/j.jep.2023.116961. Epub 2023 Aug 2. PMID: 37541404. 6: Xiong Y, Chen T, Chen L, Cai R. Gold Nanoparticles Coated with SH-PEG- NH2 and Loaded with Ziyuglycoside I for Promoting Autophagy in Hematopoietic Stem Cells. Int J Nanomedicine. 2023 Mar 21;18:1347-1362. doi: 10.2147/IJN.S399568. PMID: 36974074; PMCID: PMC10039662. 7: Wang M, Su T, Sun H, Cheng H, Jiang C, Guo P, Zhu Z, Fang R, He F, Ge M, Guan Q, Wei W, Wang Q. Regulating Th17/Treg Balance Contributes to the Therapeutic Effect of Ziyuglycoside I on Collagen-Induced Arthritis. Int J Mol Sci. 2022 Dec 17;23(24):16105. doi: 10.3390/ijms232416105. PMID: 36555745; PMCID: PMC9786935. 8: Wei F, Yang C, Wu L, Sun J, Wang Z, Wang Z. Simultaneous Determination and Pharmacokinetics Study of Three Triterpenes from Sanguisorba officinalis L. in Rats by UHPLC-MS/MS. Molecules. 2022 Aug 24;27(17):5412. doi: 10.3390/molecules27175412. PMID: 36080179; PMCID: PMC9458004. 9: Sun H, Wang M, Su T, Guo P, Tai Y, Cheng H, Zhu Z, Jiang C, Yan S, Wei W, Zhang L, Wang Q. Ziyuglycoside I attenuates collagen-induced arthritis through inhibiting plasma cell expansion. J Ethnopharmacol. 2022 Aug 10;294:115348. doi: 10.1016/j.jep.2022.115348. Epub 2022 May 6. PMID: 35533910. 10: Song T, Wang H, Liu Y, Cai R, Yang D, Xiong Y. TPGS-Modified Long- Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression. Int J Nanomedicine. 2021 Sep 14;16:6281-6295. doi: 10.2147/IJN.S326629. PMID: 34548791; PMCID: PMC8449650. 11: Park KR, Lee JY, Cho M, Yun HM. Ziyuglycoside I Upregulates RUNX2 through ERK1/2 in Promoting Osteoblast Differentiation and Bone Mineralization. Am J Chin Med. 2021;49(4):883-900. doi: 10.1142/S0192415X21500427. Epub 2021 Apr 7. PMID: 33829967. 12: Zhu LJ, Chen L, Bai CF, Wu AG, Liang SC, Huang FH, Cao SS, Yang L, Zou WJ, Wu JM. A rapid and sensitive UHPLC-MS/MS method for the determination of ziyuglycoside I and its application in a preliminary pharmacokinetic study in healthy and leukopenic rats. Biomed Pharmacother. 2020 Mar;123:109756. doi: 10.1016/j.biopha.2019.109756. Epub 2019 Dec 25. PMID: 31864212. 13: Yun MY, Bae EY, Lee SW, Yim SH, Ly SY, Choi HJ. Anti-photoaging effect of skin cream manufactured with ziyuglycoside I isolated from Sanguisorba officinalis on ultraviolet B-induced hairless mice. Biosci Biotechnol Biochem. 2019 Jul;83(7):1197-1204. doi: 10.1080/09168451.2019.1607247. Epub 2019 Apr 19. PMID: 30999820. 14: Xiong Y, Zou Y, Chen L, Xu Y, Wang S. Development and In Vivo Evaluation of Ziyuglycoside I-Loaded Self-Microemulsifying Formulation for Activity of Increasing Leukocyte. AAPS PharmSciTech. 2019 Feb 5;20(3):101. doi: 10.1208/s12249-019-1313-3. PMID: 30721444; PMCID: PMC6373417. 15: Yoshida H, Yamazaki K, Komiya A, Aoki M, Kasamatsu S, Murata T, Sayo T, Cilek MZ, Okada Y, Takahashi Y. Inhibitory effects of Sanguisorba officinalis root extract on HYBID (KIAA1199)-mediated hyaluronan degradation and skin wrinkling. Int J Cosmet Sci. 2019 Feb;41(1):12-20. doi: 10.1111/ics.12505. Epub 2019 Jan 9. PMID: 30485450. 16: Wu C, Yao M, Li W, Cui B, Dong H, Ren Y, Yang C, Gan C. Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of Sanguisorba officinalis L. Extract. Molecules. 2018 Nov 15;23(11):2980. doi: 10.3390/molecules23112980. PMID: 30445715; PMCID: PMC6278537. 17: Li ZF, Zhou MY, Tan T, Zhong CC, Wang Q, Pan LL, Luo YY, Yang SL, Feng YL, Ouyang H. A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics. Molecules. 2018 Feb 28;23(3):543. doi: 10.3390/molecules23030543. PMID: 29495641; PMCID: PMC6017276. 18: Jang E, Inn KS, Jang YP, Lee KT, Lee JH. Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review. Am J Chin Med. 2018;46(2):299-318. doi: 10.1142/S0192415X18500155. Epub 2018 Feb 12. PMID: 29433389. 19: Zhu X, Wang K, Yao Y, Zhang K, Zhou F, Zhu L. Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22001. Epub 2017 Sep 28. PMID: 28960612. 20: Xiong YA, Yang M. [Effects of sanguisorba tannins and saponins compatibility on pharmacokinetic parameters of catechin, epicatechin and ziyuglycoside Ⅰ in rats]. Zhongguo Zhong Yao Za Zhi. 2016 Oct;41(19):3661-3667. Chinese. doi: 10.4268/cjcmm20161927. PMID: 28925165.

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