LY-3499446 | CAS#2409131-50-4 | KRAS G12C inhibitor

MedKoo Cat#: 145344 | Name: LY-3499446

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-3499446 is a small molecule that has been developed to specifically target K-RAS G12C.

Chemical Structure

LY-3499446

CAS#2409131-50-4

Theoretical Analysis

MedKoo Cat#: 145344

Name: LY-3499446

CAS#: 2409131-50-4

Chemical Formula: C22H17ClF2N6OS

Exact Mass: 486.0841

Molecular Weight: 486.93

Elemental Analysis: C, 54.27; H, 3.52; Cl, 7.28; F, 7.80; N, 17.26; O, 3.29; S, 6.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

LY-3499446; LY3499446; LY 3499446;

IUPAC/Chemical Name

1-(4-(7-(2-amino-7-fluorobenzo[d]thiazol-4-yl)-6-chloro-8-fluoroquinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

InChi Key

YNBBKDMAVRSYRE-UHFFFAOYSA-N

InChi Code

1S/C22H17ClF2N6OS/c1-2-15(32)30-5-7-31(8-6-30)21-12-9-13(23)16(17(25)18(12)27-10-28-21)11-3-4-14(24)20-19(11)29-22(26)33-20/h2-4,9-10H,1,5-8H2,(H2,26,29)

SMILES Code

NC1=NC2=C(C=CC(F)=C2S1)C3=C(F)C4=C(C=C3Cl)C(=NC=N4)N5CCN(CC5)C(=O)C=C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 486.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Uprety D, Adjei AA. KRAS: From undruggable to a druggable Cancer Target. Cancer Treat Rev. 2020 Sep;89:102070. doi: 10.1016/j.ctrv.2020.102070. Epub 2020 Jul 15. PMID: 32711246. 2: Nagasaka M, Li Y, Sukari A, Ou SI, Al-Hallak MN, Azmi AS. KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne? Cancer Treat Rev. 2020 Mar;84:101974. doi: 10.1016/j.ctrv.2020.101974. Epub 2020 Jan 23. PMID: 32014824; PMCID: PMC7041424.