SMIP-30 | CAS#2919466-30-9 | PPM1A inhibitor

MedKoo Cat#: 208369 | Name: SMIP-30

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMIP-30 is a small molecule inhibitor for PPM1A. SMIP-30 provides proof of concept that PPMs are druggable and promising targets for the development of host-directed therapies against tuberculosis.

Chemical Structure

SMIP-30

CAS#2919466-30-9 (bromide)

Theoretical Analysis

MedKoo Cat#: 208369

Name: SMIP-30

CAS#: 2919466-30-9 (bromide)

Chemical Formula: C16H15BrFNO2

Exact Mass: 351.0270

Molecular Weight: 352.20

Elemental Analysis: C, 54.56; H, 4.29; Br, 22.69; F, 5.39; N, 3.98; O, 9.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2919466-29-6 (cation) 2919466-30-9 (bromide)

Synonym

SMIP30, S-MIP-30

IUPAC/Chemical Name

2-Fluoro-5-(2-hydroxyethyl)-8-methoxyphenanthridin-5-ium bromide

InChi Key

ZBKGDGWEQRMRGD-UHFFFAOYSA-M

InChi Code

InChI=1S/C16H15FNO2.BrH/c1-20-13-3-4-14-11(8-13)10-18(6-7-19)16-5-2-12(17)9-15(14)16;/h2-5,8-10,19H,6-7H2,1H3;1H/q+1;/p-1

SMILES Code

COC1=CC=C2C(C=[N+](CCO)C3=C2C=C(F)C=C3)=C1.[Br-]

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 352.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Berton S, Chen L, Liang YC, Xu Z, Afriyie-Asante A, Rajabalee N, Yang W, Sun J. A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis. Cell Chem Biol. 2022 Jul 21;29(7):1126-1139.e12. doi: 10.1016/j.chembiol.2022.03.006. Epub 2022 Mar 22. PMID: 35320734. Liang YC, Berton S, Reeks C, Sun J. An in vivo biosafety-level-2-compatible model of Mycobacterium tuberculosis infection for drug susceptibility testing. STAR Protoc. 2022 Jul 19;3(3):101575. doi: 10.1016/j.xpro.2022.101575. PMID: 35880128; PMCID: PMC9307682.