ZXH-4-130 | CAS# 2711006-66-3 | PROTAC

MedKoo Cat#: 121010 | Name: ZXH-4-130

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZXH-4-130 is a PROTAC compound.

Chemical Structure

ZXH-4-130

CAS#2711006-66-3

Theoretical Analysis

MedKoo Cat#: 121010

Name: ZXH-4-130

CAS#: 2711006-66-3

Chemical Formula: C47H60N6O9S

Exact Mass: 884.4142

Molecular Weight: 885.09

Elemental Analysis: C, 63.78; H, 6.83; N, 9.50; O, 16.27; S, 3.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ZXH-4-130; ZXH4-130; ZXH 4-130

IUPAC/Chemical Name

(2S,4R)-1-((2S)-2-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)dodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

InChi Key

QJBXLKXRPSKFSJ-BBMAHLSPSA-N

InChi Code

InChI=1S/C47H60N6O9S/c1-29-40(63-28-49-29)31-20-18-30(19-21-31)26-48-42(57)35-25-32(54)27-52(35)46(61)41(47(2,3)4)50-37(55)17-12-10-8-6-5-7-9-11-13-24-62-36-16-14-15-33-39(36)45(60)53(44(33)59)34-22-23-38(56)51-43(34)58/h14-16,18-21,28,32,34-35,41,54H,5-13,17,22-27H2,1-4H3,(H,48,57)(H,50,55)(H,51,56,58)/t32-,34?,35+,41-/m1/s1

SMILES Code

O[C@H]1CN(C([C@H](C(C)(C)C)NC(CCCCCCCCCCCOC2=C(C(N(C3C(NC(CC3)=O)=O)C4=O)=O)C4=CC=C2)=O)=O)[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 885.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Powell CE, Du G, Bushman JW, He Z, Zhang T, Fischer ES, Gray NS. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021 Jul 6;12(8):1381-1390. doi: 10.1039/d0md00382d. PMID: 34458741; PMCID: PMC8372211.