Tuvusertib, also known as M-1774 and ATR inhibitor 1, is a ATR inhibitor. M1774 selectively inhibits ATR activity and blocks the downstream phosphorylation of the serine/threonine protein kinase checkpoint kinase 1 (CHK1). This prevents ATR-mediated signaling, which results in the inhibition of DNA damage checkpoint activation, the disruption of DNA damage repair, and the induction of tumor cell apoptosis.
MedKoo Cat#: 408177
Name: Tuvusertib
CAS#: 1613200-51-3
Chemical Formula: C16H12F2N8O
Exact Mass: 370.1102
Molecular Weight: 370.32
Elemental Analysis: C, 51.89; H, 3.27; F, 10.26; N, 30.26; O, 4.32
The following data is based on the product molecular weight 370.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
