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MedKoo Cat#: 112188 | Name: Pestalotin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pestalotin is cytotoxic to HL-60, MKN45, LoVo, and A549 cells (IC50s = 64.87-182.92 μM).

Chemical Structure

Pestalotin
CAS#34565-32-7

Theoretical Analysis

MedKoo Cat#: 112188

Name: Pestalotin

CAS#: 34565-32-7

Chemical Formula: C11H18O4

Exact Mass: 214.1205

Molecular Weight: 214.26

Elemental Analysis: C, 61.66; H, 8.47; O, 29.87

Price and Availability

Size Price Availability Quantity
2.5mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
Pestalotin; (−)-Pestalotin
IUPAC/Chemical Name
(S)-6-((S)-1-hydroxypentyl)-4-methoxy-5,6-dihydro-2H-pyran-2-one
InChi Key
YFIMUDXPJZVJJO-UWVGGRQHSA-N
InChi Code
InChI=1S/C11H18O4/c1-3-4-5-9(12)10-6-8(14-2)7-11(13)15-10/h7,9-10,12H,3-6H2,1-2H3/t9-,10-/m0/s1
SMILES Code
O=C1O[C@@]([H])(CC(OC)=C1)[C@H](CCCC)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 214.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Labuda R, Bacher M, Rosenau T, Gasparotto E, Gratzl H, Doppler M, Sulyok M, Kubátová A, Berger H, Cank K, Raja HA, Oberlies NH, Schüller C, Strauss J. Polyphasic Approach Utilized for the Identification of Two New Toxigenic Members of Penicillium Section Exilicaulis, P. krskae and P. silybi spp. nov. J Fungi (Basel). 2021 Jul 13;7(7):557. doi: 10.3390/jof7070557. PMID: 34356936; PMCID: PMC8307998. 2: Le VT, Bertrand S, Robiou du Pont T, Fleury F, Caroff N, Bourgeade-Delmas S, Gentil E, Logé C, Genta-Jouve G, Grovel O. Untargeted Metabolomics Approach for the Discovery of Environment-Related Pyran-2-ones Chemodiversity in a Marine- Sourced Penicillium restrictum. Mar Drugs. 2021 Jun 29;19(7):378. doi: 10.3390/md19070378. PMID: 34210084; PMCID: PMC8305465. 3: Gallo A, Ghilardelli F, Atzori AS, Zara S, Novak B, Faas J, Fancello F. Co- Occurrence of Regulated and Emerging Mycotoxins in Corn Silage: Relationships with Fermentation Quality and Bacterial Communities. Toxins (Basel). 2021 Mar 23;13(3):232. doi: 10.3390/toxins13030232. PMID: 33806727; PMCID: PMC8004697. 4: Moriyama M, Nakata K, Fujiwara T, Tanabe Y. Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (R)-Glycidol. Molecules. 2020 Jan 17;25(2):394. doi: 10.3390/molecules25020394. PMID: 31963564; PMCID: PMC7024299. 5: Nalin Rathnayake GR, Savitri Kumar N, Jayasinghe L, Araya H, Fujimoto Y. Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora. Nat Prod Bioprospect. 2019 Dec;9(6):411-417. doi: 10.1007/s13659-019-00225-0. Epub 2019 Nov 15. PMID: 31729648; PMCID: PMC6872701. 6: Guo W, Wang S, Li N, Li F, Zhu T, Gu Q, Guo P, Li D. Saroclides A and B, Cyclic Depsipeptides from the Mangrove-Derived Fungus Sarocladium kiliense HDN11-112. J Nat Prod. 2018 Apr 27;81(4):1050-1054. doi: 10.1021/acs.jnatprod.7b00644. Epub 2018 Mar 2. PMID: 29498850. 7: Rivera-Chávez J, Figueroa M, González Mdel C, Glenn AE, Mata R. α-Glucosidase Inhibitors from a Xylaria feejeensis Associated with Hintonia latiflora. J Nat Prod. 2015 Apr 24;78(4):730-5. doi: 10.1021/np500897y. Epub 2015 Feb 23. PMID: 25706243.