Sodium catechol sulfate | CAS#149-45-1

MedKoo Cat#: 531741 | Name: Sodium catechol sulfate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sodium catechol sulfate is a bioactive chemical.

Chemical Structure

Sodium catechol sulfate

CAS#149-45-1 (sodium)

Theoretical Analysis

MedKoo Cat#: 531741

Name: Sodium catechol sulfate

CAS#: 149-45-1 (sodium)

Chemical Formula: C6H4Na2O8S2

Exact Mass: 0.0000

Molecular Weight: 314.19

Elemental Analysis: C, 22.94; H, 1.28; Na, 14.63; O, 40.74; S, 20.41

Price and Availability

Size	Price	Availability	Quantity
25g	USD 260.00	2 Weeks
250g	USD 575.00	2 Weeks

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Related CAS #

149-46-2 (free acid) 149-45-1 (sodium)

Synonym

Sodium catechol sulfate; Tiferron; Tiron; WAS-21; WAS 21; WAS21;

IUPAC/Chemical Name

1,2-Dihydroxybenzene-3,5-disulfonic acid disodium salt

InChi Key

ISWQCIVKKSOKNN-UHFFFAOYSA-L

InChi Code

InChI=1S/C6H6O8S2.2Na/c7-4-1-3(15(9,10)11)2-5(6(4)8)16(12,13)14;;/h1-2,7-8H,(H,9,10,11)(H,12,13,14);;/q;2*+1/p-2

SMILES Code

O=S(C1=C(O)C(O)=CC(S(=O)([O-])=O)=C1)([O-])=O.[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Sodium catechol sulfate is a non-toxic chelator of a variety of metals.

In vitro activity:

Sodium catechol sulfate has potential for preventing and treating UV-induced skin photoaging. In human dermal fibroblast cells, sodium catechol sulfate inhibited ultraviolet B (UVB)-induced protein expression of MMP-1 and MMP-3. Sodium catechol sulfate significantly blocked UVB-induced activation of the MAPK signaling pathway and activator protein (AP)-1 in the downstream of this transduction pathway in fibroblasts. Reference: PLoS One. 2016 Aug 3;11(8):e0159998. https://pubmed.ncbi.nlm.nih.gov/27486852/

In vivo activity:

Sodium catechol sulfateprevented acetic acid-induced colitis in rats via modulating inflammatory pathway TGF-β1/P-EGFR/PI3K/AKT/NF-κB, alongside managing the oxidant/antioxidant equilibrium, and boosting the reliability of the intestinal barrier. Sodium catechol sulfate administration significantly diminished lactate dehydrogenase, C-reactive protein, colon weight, and the weight/length ratio of the colon as compared to acetic acid-injected rats. Reference: Int Immunopharmacol. 2024 Jan 27;128:111587. https://pubmed.ncbi.nlm.nih.gov/38286073/

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	83.3	265.21

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 314.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Lu J, Guo JH, Tu XL, Zhang C, Zhao M, Zhang QW, Gao FH. Tiron Inhibits UVB-Induced AP-1 Binding Sites Transcriptional Activation on MMP-1 and MMP-3 Promoters by MAPK Signaling Pathway in Human Dermal Fibroblasts. PLoS One. 2016 Aug 3;11(8):e0159998. doi: 10.1371/journal.pone.0159998. PMID: 27486852; PMCID: PMC4972414. 2. Krishna CM, Liebmann JE, Kaufman D, DeGraff W, Hahn SM, McMurry T, Mitchell JB, Russo A. The catecholic metal sequestering agent 1,2-dihydroxybenzene-3,5-disulfonate confers protection against oxidative cell damage. Arch Biochem Biophys. 1992 Apr;294(1):98-106. doi: 10.1016/0003-9861(92)90142-j. PMID: 1312813. 3. El Mahdy RN, Nader MA, Helal MG, Abu-Risha SE, Abdelmageed ME. Tiron ameliorates acetic acid-induced colitis in rats: Role of TGF-β/EGFR/PI3K/NF-κB signaling pathway. Int Immunopharmacol. 2024 Jan 27;128:111587. doi: 10.1016/j.intimp.2024.111587. Epub ahead of print. PMID: 38286073. 4. Khaled S, Makled MN, Nader MA. Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo. Life Sci. 2020 Nov 1;260:118426. doi: 10.1016/j.lfs.2020.118426. Epub 2020 Sep 13. PMID: 32937159.

In vitro protocol:

In vivo protocol:

1. El Mahdy RN, Nader MA, Helal MG, Abu-Risha SE, Abdelmageed ME. Tiron ameliorates acetic acid-induced colitis in rats: Role of TGF-β/EGFR/PI3K/NF-κB signaling pathway. Int Immunopharmacol. 2024 Jan 27;128:111587. doi: 10.1016/j.intimp.2024.111587. Epub ahead of print. PMID: 38286073. 2. Khaled S, Makled MN, Nader MA. Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo. Life Sci. 2020 Nov 1;260:118426. doi: 10.1016/j.lfs.2020.118426. Epub 2020 Sep 13. PMID: 32937159.

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