TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2, and selectively kills cancer cells. TH9619 targets nuclear MTHFD2 but does not inhibit mitochondrial MTHFD2. TH9619 inhibits the activity of MTHFD1 occurring downstream of mitochondrial formate release, leading to the accumulation of 10-formyl-tetrahydrofolate.
MedKoo Cat#: 208283
Name: TH9619 sodium
CAS#: TH9619 sodium
Chemical Formula: C17H17N7Na2O7
Exact Mass: 433.1346
Molecular Weight: 477.34
Elemental Analysis: C, 42.78; H, 3.59; N, 20.54; Na, 9.63; O, 23.46
The following data is based on the product molecular weight 477.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
