MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein−Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model.
MedKoo Cat#: 207180
Name: MRTX0902
CAS#: 2654743-22-1
Chemical Formula: C22H24N6O
Exact Mass: 388.2012
Molecular Weight: 388.48
Elemental Analysis: C, 68.02; H, 6.23; N, 21.63; O, 4.12
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMSO | 125.0 | 321.77 |
The following data is based on the product molecular weight 388.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |