ZLWH-23 | CAS# 2765251-12-3 | Inhibitor

MedKoo Cat#: 208188 | Name: ZLWH-23

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ZLWH-23 displayed efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model. Collectively, harmine-based derivatives could be considered as possible drug leads for the development of AD therapies.

Chemical Structure

ZLWH-23

CAS# 2765251-12-3

Theoretical Analysis

MedKoo Cat#: 208188

Name: ZLWH-23

CAS#: 2765251-12-3

Chemical Formula: C30H32FN5O2

Exact Mass: 513.2540

Molecular Weight: 513.62

Elemental Analysis: C, 70.16; H, 6.28; F, 3.70; N, 13.64; O, 6.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ZLWH23, ZLWH 23, ZL-WH23

IUPAC/Chemical Name

1-(Cyclopropanecarboxamido)-N-(2-(1-(2-fluorobenzyl)piperidin-4-yl)ethyl)-9H-pyrido[3,4-b]indole-7-carboxamide

InChi Key

AMLAWNFGPZNOOW-UHFFFAOYSA-N

InChi Code

InChI=1S/C30H32FN5O2/c31-25-4-2-1-3-22(25)18-36-15-11-19(12-16-36)9-13-33-29(37)21-7-8-23-24-10-14-32-28(27(24)34-26(23)17-21)35-30(38)20-5-6-20/h1-4,7-8,10,14,17,19-20,34H,5-6,9,11-13,15-16,18H2,(H,33,37)(H,32,35,38)

SMILES Code

O=C(C1=CC2=C(C=C1)C3=C(C(NC(C4CC4)=O)=NC=C3)N2)NCCC5CCN(CC6=CC=CC=C6F)CC5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 513.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Liu W, Liu X, Liu W, Gao Y, Wu L, Huang Y, Chen H, Li D, Zhou L, Wang N, Xu Z, Jiang X, Zhao Q. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Feb 5;229:114095. doi: 10.1016/j.ejmech.2021.114095. Epub 2021 Dec 30. PMID: 34995924.