WFQ-228 | CAS#unknown | Fluoroquinolone antibiotic

MedKoo Cat#: 464659 | Name: WFQ-228

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WFQ-228 is a novel fluoroquinolone antibiotic with potent antimicrobial activity, showing the potential to overcome major drug resistance; its antimicrobial activity was less affected by both pump-mediated efflux and QRDR mutations in P. aeruginosa compared with LVX and CIP.

Chemical Structure

WFQ-228

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464659

Name: WFQ-228

CAS#: unknown

Chemical Formula: C22H21ClF2N4O4

Exact Mass: 478.1219

Molecular Weight: 478.88

Elemental Analysis: C, 55.18; H, 4.42; Cl, 7.40; F, 7.93; N, 11.70; O, 13.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

WFQ-228; WFQ228; WFQ 228;

IUPAC/Chemical Name

1-(5-amino-4-fluoro-2-(hydroxymethyl)phenyl)-8-chloro-6-fluoro-5-methyl-7-(3-(methylamino)azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

InChi Key

BUYCHMJCHCPDRG-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H21ClF2N4O4/c1-9-16-19(17(23)20(18(9)25)28-5-11(6-28)27-2)29(7-12(21(16)31)22(32)33)15-4-14(26)13(24)3-10(15)8-30/h3-4,7,11,27,30H,5-6,8,26H2,1-2H3,(H,32,33)

SMILES Code

O=C(C1=CN(C2=CC(N)=C(F)C=C2CO)C3=C(C(C)=C(F)C(N4CC(NC)C4)=C3Cl)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 478.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Qiao M, Ren W, Guo H, Huo F, Shang Y, Wang Y, Gao M, Pang Y. Comparative in vitro susceptibility of a novel fluoroquinolone antibiotic candidate WFQ-228, levofloxacin, and moxifloxacin against Mycobacterium tuberculosis. Int J Infect Dis. 2021 Apr 20;106:295-299. doi: 10.1016/j.ijid.2021.04.036. Epub ahead of print. PMID: 33864922. 2: Hirano T, Kinoshita T, Kazamori D, Inoue S, Nishimura K, Sakurai A, Ohishi K, Kuramoto Y, Amano H, Yazaki A. Discovery of a Novel Fluoroquinolone Antibiotic Candidate WFQ-228 with Potent Antimicrobial Activity and the Potential to Overcome Major Drug Resistance. Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):235-238. doi: 10.1248/cpb.c17-00717. Epub 2018 Jan 11. PMID: 29321384.