Synonym
WFQ-228; WFQ228; WFQ 228;
IUPAC/Chemical Name
1-(5-amino-4-fluoro-2-(hydroxymethyl)phenyl)-8-chloro-6-fluoro-5-methyl-7-(3-(methylamino)azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
InChi Key
BUYCHMJCHCPDRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H21ClF2N4O4/c1-9-16-19(17(23)20(18(9)25)28-5-11(6-28)27-2)29(7-12(21(16)31)22(32)33)15-4-14(26)13(24)3-10(15)8-30/h3-4,7,11,27,30H,5-6,8,26H2,1-2H3,(H,32,33)
SMILES Code
O=C(C1=CN(C2=CC(N)=C(F)C=C2CO)C3=C(C(C)=C(F)C(N4CC(NC)C4)=C3Cl)C1=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
478.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Qiao M, Ren W, Guo H, Huo F, Shang Y, Wang Y, Gao M, Pang Y. Comparative in vitro susceptibility of a novel fluoroquinolone antibiotic candidate WFQ-228, levofloxacin, and moxifloxacin against Mycobacterium tuberculosis. Int J Infect Dis. 2021 Apr 20;106:295-299. doi: 10.1016/j.ijid.2021.04.036. Epub ahead of print. PMID: 33864922.
2: Hirano T, Kinoshita T, Kazamori D, Inoue S, Nishimura K, Sakurai A, Ohishi K, Kuramoto Y, Amano H, Yazaki A. Discovery of a Novel Fluoroquinolone Antibiotic Candidate WFQ-228 with Potent Antimicrobial Activity and the Potential to Overcome Major Drug Resistance. Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):235-238. doi: 10.1248/cpb.c17-00717. Epub 2018 Jan 11. PMID: 29321384.
