MedKoo Cat#: 556115 | Name: SR15006
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR15006 is a inhibitor of Krüppel-like factor 5 (KLF5) . SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. SR18662 significantly reduces growth and proliferation of colorectal cancer cells as compared with treatment with vehicle control, SR18662 showed improved efficacy in reducing the viability of multiple colorectal cancer cell lines. SR18662 treatment also reduces the expression of cyclins and components of the MAPK and WNT signaling pathways.

Chemical Structure

SR15006
CAS#2505001-54-5

Theoretical Analysis

MedKoo Cat#: 556115

Name: SR15006

CAS#: 2505001-54-5

Chemical Formula: C16H20ClN3O4S

Exact Mass: 385.0863

Molecular Weight: 385.86

Elemental Analysis: C, 49.80; H, 5.22; Cl, 9.19; N, 10.89; O, 16.59; S, 8.31

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,050.00 2 Weeks
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Related CAS #
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Synonym
SR15006; SR-15006; SR 15006
IUPAC/Chemical Name
(E)-3-(3-chlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide
InChi Key
DURMLOBZTVQDGQ-AATRIKPKSA-N
InChi Code
InChI=1S/C16H20ClN3O4S/c1-25(23,24)20-9-7-19(8-10-20)16(22)12-18-15(21)6-5-13-3-2-4-14(17)11-13/h2-6,11H,7-10,12H2,1H3,(H,18,21)/b6-5+
SMILES Code
O=C(NCC(N1CCN(S(=O)(C)=O)CC1)=O)/C=C/C2=CC=CC(Cl)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 385.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Kim J, Wang C, de Sabando AR, Cole HL, Huang TJ, Yang J, Bannister TD, Yang VW, Bialkowska AB. The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal Cancer In Vitro and In Vivo. Mol Cancer Ther. 2019 Nov;18(11):1973-1984. doi: 10.1158/1535-7163.MCT-18-1366. Epub 2019 Jul 29. PMID: 31358661; PMCID: PMC6825545.