Bromazine HCl | CAS#1808-12-4 | Antihistaminic

MedKoo Cat#: 592774 | Name: Bromazine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromazine (trade names Ambodryl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic. It is a brominated form of diphenhydramine.

Chemical Structure

Bromazine HCl

CAS#1808-12-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 592774

Name: Bromazine HCl

CAS#: 1808-12-4 (HCl)

Chemical Formula: C17H21BrClNO

Exact Mass: 0.0000

Molecular Weight: 370.72

Elemental Analysis: C, 55.08; H, 5.71; Br, 21.55; Cl, 9.56; N, 3.78; O, 4.32

Price and Availability

Size	Price	Availability
100mg	USD 450.00	2 weeks
200mg	USD 750.00	2 weeks
500mg	USD 1,650.00	2 weeks
1g	USD 2,950.00	2 weeks
2g	USD 4,250.00	2 weeks
5g	USD 6,950.00	2 weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

118-23-0 (free base) 1808-12-4 (HCl)

Synonym

Bromodiphenhydramine hydrochloride; Bromazine HCl; Bromazine hydrohloride

IUPAC/Chemical Name

2-((4-Bromophenyl)phenylmethoxy)ethyl(dimethyl)ammonium chloride

InChi Key

ZQDJSWUEGOYDGT-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H

SMILES Code

C[NH+](CCOC(C1=CC=C(Br)C=C1)C2=CC=CC=C2)C.[Cl-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: MACLAREN WR, BRUFF WC, EISENBERG BC, WEINER H, MARTIN WH. A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms. Ann Allergy. 1955 May-Jun;13(3):307-12. PubMed PMID: 14377226. 2: MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish. PubMed PMID: 13771809. 3: Attwood D, Udeala OK. Aggregation of antihistamines in aqueous solution. The effect of electrolyte on the miscellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1975 Jun;27(6):395-9. PubMed PMID: 237086. 4: Ray S, Chattopadhyay D, Dastidar SG, Chakrabarty AN. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8. PubMed PMID: 1973150. 5: DE MATTEIS M, RIMOLDI R. [Clinico-statistical research on a hypnotic & sedative drug (bromodiphenhydramine ethinamate)]. Minerva Med. 1959 Mar 21;50(23):823-7. Italian. PubMed PMID: 13656702. 6: Ahmadi A, Khalili M, Nafarie A, Yazdani A, Nahri-Niknafs B. Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs. Mini Rev Med Chem. 2012 Oct;12(12):1282-92. PubMed PMID: 22876948. 7: Fusari SA, Terhalle M, Holcomb IJ, Alix EC. Reverse phase thin-layer chromatographic separation of bromodiphenhydramine and diphenhydramine. J Chromatogr Sci. 1975 Dec;13(12):563-4. PubMed PMID: 1194397. 8: Chakrabarty AN, Acharya DP, Neogi D, Dastidar SG. Drug interaction of promethazine & other non-conventional antimicrobial chemotherapeutic agents. Indian J Med Res. 1989 Jul;89:233-7. PubMed PMID: 2807428. 9: Atherton AD, Barry BW. Photon correlation spectroscopy of surface active cationic drugs. J Pharm Pharmacol. 1985 Dec;37(12):854-62. PubMed PMID: 2868091. 10: BAIRD JA, BOYD EM. Bromazine hydrochloride and complex coordinated reflex activity. J Pharm Pharmacol. 1954 Jan;6(1):38-42. PubMed PMID: 13118513. 11: THOMAS JW, KELLY FR Jr. Further notes on the clinical use of ambodryl hydrochloride. Ann Allergy. 1952 Nov-Dec;10(6):725-6. PubMed PMID: 13017403. 12: BOYD EM, HICKS RN. The failure of bromazine hydrochloride to affect the output and composition of respiratory tract fluid. J Pharm Pharmacol. 1954 Jan;6(1):43-9. PubMed PMID: 13118514. 13: THOMAS JW, KELLY FR Jr. The clinical evaluation of ambodryl hydrochloride; a report of 100 cases. Ann Allergy. 1951 Jul-Aug;9(4):481-6. PubMed PMID: 14847432. 14: DORSCH W. [Research on the effects of the new antihistaminic Ambodryl on driving fitness]. Munch Med Wochenschr. 1961 May 12;103:1014-7. German. PubMed PMID: 13723965. 15: Ray S, Dastidar SG, Chakrabarty AN. Antibiotic cross-resistance patterns of ambodryl and promazine resistant mutants. Br J Exp Pathol. 1980 Oct;61(5):465-70. PubMed PMID: 6108782; PubMed Central PMCID: PMC2041529. 16: Chattopadhyay D, Dastidar SG, Chakrabarty AN. Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung. 1988 Jul;38(7):869-72. PubMed PMID: 2905130. 17: Ullrich KJ, Rumrich G, David C, Fritzsch G. Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch. 1993 Nov;425(3-4):280-99. PubMed PMID: 8309790. 18: Parry R, Calvert RT. The disposition of diphenhydramine and four of its analogues in rabbits and implication for structure-activity relationship studies in drug design. Biopharm Drug Dispos. 1982 Jul-Sep;3(3):255-65. PubMed PMID: 7139065. 19: McGAVACK TH, WEISSBERG J, SHEARMAN AM. Newer antihistamines; effectiveness and side effects of long-continued use of ambodryl. Ann Allergy. 1952 Mar-Apr;10(2):172-8. PubMed PMID: 14915362. 20: DESHMANKER BS, AGARWAL SL. The action of three recent antihistaminic drugs--ambodryl, sandosten and synopen on bronchial muscle. Indian J Med Sci. 1959 Sep;13:762-6. PubMed PMID: 13816133.